Summary

Name E2F4
Full Name Transcription factor E2F4
Synonyms E2F-4
Primary ID Q16254
Links - -
Type protein
Relations 3
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation

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Relations

Regulator Mechanism target score ℹ
+ E2F4down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.462
Publications: 1 Organism: Homo Sapiens
+ E2F4down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.462
Publications: 1 Organism: Homo Sapiens
+ E2F4down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BIRC5 0.334
Publications: 1