| + |
NTRK3 | up-regulates 
binding
|
SHC1 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65958 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10092678 |
We demonstrate that the phosphotyrosine binding domain of frs-2 directly binds the trk receptors at the same phosphotyrosine residue that binds the signaling adapter shc, suggesting a model in which competitive binding between frs-2 and shc regulates differentiation versus proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NTF3 | up-regulates
binding
|
NTRK3 |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-20699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1653651 |
Trkc, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NTRK3 | up-regulates
binding
|
PLCG1 |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67404 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10235685 |
Unglycosylated trka core protein is phosphorylated even in the absence of ligand stimulation and displays constitutive kinase activity as well as constitutive interaction with the signaling molecules shc and plc-gamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LSM-1231 | down-regulates activity 
chemical inhibition
|
NTRK3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258240 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
NTRK3
- 
- 