Summary

Name SHC1
Full Name SHC-transforming protein 1
Synonyms SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1 | SHC, SHCA
Primary ID P29353
Links - -
Type protein
Relations 64
Pathways Acute Myeloid Leukemia, miRNA in AML, EGFR Signaling, FLT3-ITD in AML, IL6 Signaling, Noonan syndrome, Thyroid cancer
Function Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.41
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.552
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.2
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation SHC1 0.552
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.665
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SHC1 0.577
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SHC1 0.662
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.752
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.434
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD in AML
+ down-regulates activity img/direct_inhibition.png dephosphorylation SHC1 0.2
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.654
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling, IL6 Signaling
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.721
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SHC1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.699
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.734
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SOS1 0.76
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, IL6 Signaling, Noonan syndrome, Thyroid cancer
+ up-regulates activity img/direct-activation.png binding SHC1 0.726
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png SHC1 0.431
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ up-regulates activity img/direct-activation.png relocalization SHC1 0.7
Publications: 1 Organism: Sus Scrofa Domesticus
+ up-regulates img/direct-activation.png binding SHC1 0.84
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png ERK1/2 0.708
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, IL6 Signaling, Noonan syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SHC1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.602
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.911
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Noonan syndrome
+ up-regulates activity img/indirect-activation.png MAPK1 0.701
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding SHC1 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.965
Publications: 4 Organism: Mus Musculus, Homo Sapiens, Sus Scrofa
Pathways:Acute Myeloid Leukemia, EGFR Signaling, IL6 Signaling, Noonan syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.801
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRAP 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.53
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.643
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates activity img/direct-activation.png binding SHC1 0.911
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Noonan syndrome
+ up-regulates img/direct-activation.png binding SHC1 0.401
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.435
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SHC1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding INPP5D 0.684
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates img/direct-activation.png binding SHC1 0.724
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK3 0.611
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding SHC1 0.699
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.353
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates activity img/indirect-activation.png Gbeta 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.646
Publications: 1 Organism: Homo Sapiens