| + |
AMPK | down-regulates quantity by destabilization 
phosphorylation
|
CRY1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268047 |
Ser280 |
YKKVKKNsSPPLSLY |
Homo sapiens |
|
| pmid |
sentence |
| 19833968 |
We demonstrated that the nutrient-responsive adenosine monophosphate-activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1). In mouse livers, AMPK activity and nuclear localization were rhythmic and inversely correlated with CRY1 nuclear protein abundance. Stimulation of AMPK destabilized cryptochromes and altered circadian rhythms, and mice in which the AMPK pathway was genetically disrupted showed alterations in peripheral clocks. Phosphorylation of S71 or S280 by AMPK destabilizes CRY1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268046 |
Ser71 |
ANLRKLNsRLFVIRG |
Homo sapiens |
|
| pmid |
sentence |
| 19833968 |
We demonstrated that the nutrient-responsive adenosine monophosphate-activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1). In mouse livers, AMPK activity and nuclear localization were rhythmic and inversely correlated with CRY1 nuclear protein abundance. Stimulation of AMPK destabilized cryptochromes and altered circadian rhythms, and mice in which the AMPK pathway was genetically disrupted showed alterations in peripheral clocks. Phosphorylation of S71 or S280 by AMPK destabilizes CRY1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
PRKAA1 | down-regulates
phosphorylation
|
CRY1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176472 |
Ser71 |
ANLRKLNsRLFVIRG |
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Ampk was shown to regulate the stability of the core clock component cry1 though phosphorylation of cry1 ser71, which stimulates the direct binding of the fbox protein fbxl3 to cry1, targeting it for ubiquitin-mediated degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates
phosphorylation
|
CRY1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216546 |
Ser71 |
ANLRKLNsRLFVIRG |
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Ampk was shown to regulate the stability of the core clock component cry1 though phosphorylation of cry1 ser71, which stimulates the direct binding of the fbox protein fbxl3 to cry1, targeting it for ubiquitin-mediated degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
CLOCK/BMAL1 | up-regulates quantity by expression 
transcriptional regulation
|
CRY1 |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253679 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CRY1 | down-regulates activity
binding
|
BMAL1/NPAS2 |
0.891 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20817722 |
The mammalian clock is regulated at the cellular level by a transcriptional/translational feedback loop. BMAL1/clock (or NPAS2) heterodimers activate the expression of the period (PER) and cryptochrome (CRY) genes acting as transcription factors directed to the PER and CRY promoters via E-box elements. PER and CRY proteins form heterodimers and suppress the activity of the BMAL1/clock (or NPAS2) completing the feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
RAI1 | up-regulates quantity by expression
transcriptional regulation
|
CRY1 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266842 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Hypothalamus |
| Pathways: | Circadian clock |
| + |
TIMELESS | up-regulates activity 
binding
|
CRY1 |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268053 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 23418588 |
We performed a detailed molecular characterization of TIM interactions with the core clock protein CRY1 and the DNA damage signal transducer CHK1, and found that the N-terminus of TIM is required for association with both proteins, as well as for homodimerization. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Circadian clock |
| + |
ARNTL | up-regulates quantity by expression
transcriptional regulation
|
CRY1 |
0.932 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253626 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
CRY1 |
0.943 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253631 |
|
|
|
|
| pmid |
sentence |
| 22750052 |
Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
BMAL1/NPAS2 | up-regulates quantity by expression
transcriptional regulation
|
CRY1 |
0.891 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20817722 |
The mammalian clock is regulated at the cellular level by a transcriptional/translational feedback loop. BMAL1/clock (or NPAS2) heterodimers activate the expression of the period (PER) and cryptochrome (CRY) genes acting as transcription factors directed to the PER and CRY promoters via E-box elements. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
CRY1 | down-regulates activity
binding
|
CLOCK/BMAL1 |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267975 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20817722 |
The mammalian clock is regulated at the cellular level by a transcriptional/translational feedback loop. BMAL1/clock (or NPAS2) heterodimers activate the expression of the period (PER) and cryptochrome (CRY) genes acting as transcription factors directed to the PER and CRY promoters via E-box elements. PER and CRY proteins form heterodimers and suppress the activity of the BMAL1/clock (or NPAS2) completing the feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
3.0
CRY1
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