| + |
RAI1 | up-regulates quantity by expression 
transcriptional regulation
|
CRY1 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266842 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Hypothalamus |
| Pathways: | Circadian clock |
| + |
RAI1 | up-regulates quantity by expression
transcriptional regulation
|
PER2 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266840 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
RAI1 | up-regulates quantity by expression
transcriptional regulation
|
CLOCK/BMAL1 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266844 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Hypothalamus |
| Pathways: | Circadian clock |
| + |
RAI1 | up-regulates quantity by expression
transcriptional regulation
|
ARNTL |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266843 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
RAI1 | up-regulates quantity by expression 
transcriptional regulation
|
CLOCK |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266839 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
RAI1 Transcriptionally Activates CLOCK via an Intron 1 Enhancer Element. data suggest that RAI1 binds, directly or in a complex, to the first intron of CLOCK and enhances its transcriptional activity in vitro, supporting RAI1 as a positive regulator of CLOCK and an important part of the circadian loop of transcription. Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
RAI1 | up-regulates quantity by expression
transcriptional regulation
|
PER3 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266841 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22578325 |
Data further show that haploinsufficiency of RAI1 and Rai1 in SMS fibroblasts and the mouse hypothalamus, respectively, results in the transcriptional dysregulation of the circadian clock and causes altered expression and regulation of multiple circadian genes, including PER2, PER3, CRY1, BMAL1, and others. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Hypothalamus |
| Pathways: | Circadian clock |
3.0
RAI1
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