Summary

Name IL17A
Full Name Interleukin-17A
Synonyms IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8 | CTLA8, IL17
Primary ID Q16552
Links - -
Type protein
Relations 10
Function Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KLF15 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL17RA 0.87
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation KLF3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation KLF2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF2 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF3 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png transcriptional regulation IL17A
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png transcriptional regulation IL17A 0.38
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT17 0.08
Publications: 1 Organism: Homo Sapiens