Relation Results

Summary

Name KLF2
Full Name Krueppel-like factor 2
Synonyms Lung krueppel-like factor | LKLF
Primary ID Q9Y5W3
Links - -
Type protein
Relations 10
Pathways Acute Myeloid Leukemia, miRNA in AML, Myoblast: GH-mediated fusion
Function Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (Pub ...
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Type: Score: Layout: SPV 
0.4210.2650.2840.20.4690.2440.4320.4KLF2PPARGNPNTIL17ARELNMAPK7HBE1THBDmir-143

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Relations
Regulator
Mechanism
target
score ℹ
+ KLF2down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.421
Identifier Residue Sequence Organism Cell Line
SIGNOR-210019 Homo sapiens
pmid sentence
Constitutive overexpression of klf2 but not klf15 potently inhibits peroxisome proliferator-activated receptor-gamma (ppargamma) expression with no effect on the upstream regulators c/ebpbeta and c/ebpdelta.
Publications: 1 Organism: Homo Sapiens
+ KLF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NPNT 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-255456 Homo sapiens Skeletal Muscle Satellite Cell
pmid sentence
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ KLF2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.421
Identifier Residue Sequence Organism Cell Line
SIGNOR-95519 Homo sapiens
pmid sentence
Constitutive overexpression of klf2 but not klf15 potently inhibits peroxisome proliferator-activated receptor-gamma (ppargamma) expression with no effect on the upstream regulators c/ebpbeta and c/ebpdelta.
Publications: 1 Organism: Homo Sapiens
+ IL17Aup-regulates img/indirect-activation.png transcriptional regulation KLF2 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-210111 Homo sapiens
pmid sentence
Specifically, il-17 suppresses klf15, a pro-adipogenic tf, and enhances expression of klf2 and klf3, which are anti-adipogenic. 
Publications: 1 Organism: Homo Sapiens
+ KLF2up-regulates quantity by expression img/direct-activation.png transcriptional regulation RELN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266048 Homo sapiens
pmid sentence
KLF2 transactivates the reelin promoter in K562 cells.
Publications: 1 Organism: Homo Sapiens
+ MAPK7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF2 0.469
Identifier Residue Sequence Organism Cell Line
SIGNOR-255454 Homo sapiens Skeletal Muscle Satellite Cell
pmid sentence
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ IL17Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF2 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-192477 Homo sapiens
pmid sentence
Specifically, il-17 suppresses klf15, a pro-adipogenic tf, and enhances expression of klf2 and klf3, which are anti-adipogenic.
Publications: 1 Organism: Homo Sapiens
+ KLF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBE1 0.244
Identifier Residue Sequence Organism Cell Line
SIGNOR-251830 Mus musculus
pmid sentence
Our results show that KLF2 positively regulates the human (ε) and murine (Ey and βh1) embryonic globin genes at both E10.5 and E12.5, in the yolk sac, which is the site of primitive erythropoiesis.
Publications: 1 Organism: Mus Musculus
+ KLF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation THBD 0.432
Identifier Residue Sequence Organism Cell Line
SIGNOR-254543 Homo sapiens
pmid sentence
Thrombomodulin upregulation was independent of NF-kappaB signaling, a principal target of proteasome inhibitors, but was instead a direct consequence of increased expression of the Krüppel-like transcription factors, KLF2 and KLF4.
Publications: 1 Organism: Homo Sapiens
+ KLF2up-regulates quantity img/direct-activation.png transcriptional regulation mir-143 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-255769 Homo sapiens
pmid sentence
Overexpression of miR-155 leads to the activation of the PI3K-Akt pathway through negative regulation of Src Homology 2 domain-containing Inositol-5-Phosphatase (SHIP1).
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
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