| + |
KLF2 | up-regulates quantity by expression 
transcriptional regulation
|
HBE1 |
0.246 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251830 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15947087 |
Our results show that KLF2 positively regulates the human (ε) and murine (Ey and βh1) embryonic globin genes at both E10.5 and E12.5, in the yolk sac, which is the site of primitive erythropoiesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF2 | up-regulates quantity by expression 
transcriptional regulation
|
RELN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21530336 |
KLF2 transactivates the reelin promoter in K562 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | up-regulates quantity
transcriptional regulation
|
mir-143 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25477897 |
Overexpression of miR-155 leads to the activation of the PI3K-Akt pathway through negative regulation of Src Homology 2 domain-containing Inositol-5-Phosphatase (SHIP1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
KLF2 | up-regulates quantity by expression
transcriptional regulation
|
NPNT |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255456 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
MAPK7 | up-regulates quantity by expression
transcriptional regulation
|
KLF2 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255454 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
IL17A | up-regulates quantity by expression
transcriptional regulation
|
KLF2 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23332504 |
Specifically, il-17 suppresses klf15, a pro-adipogenic tf, and enhances expression of klf2 and klf3, which are anti-adipogenic. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | down-regulates quantity by repression 
transcriptional regulation
|
PPARG |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12426306 |
Constitutive overexpression of klf2 but not klf15 potently inhibits peroxisome proliferator-activated receptor-gamma (ppargamma) expression with no effect on the upstream regulators c/ebpbeta and c/ebpdelta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | down-regulates
transcriptional regulation
|
PPARG |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12426306 |
Constitutive overexpression of klf2 but not klf15 potently inhibits peroxisome proliferator-activated receptor-gamma (ppargamma) expression with no effect on the upstream regulators c/ebpbeta and c/ebpdelta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | up-regulates quantity by expression
transcriptional regulation
|
THBD |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254543 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19661484 |
Thrombomodulin upregulation was independent of NF-kappaB signaling, a principal target of proteasome inhibitors, but was instead a direct consequence of increased expression of the Krüppel-like transcription factors, KLF2 and KLF4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL17A | up-regulates
transcriptional regulation
|
KLF2 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23332504 |
Specifically, il-17 suppresses klf15, a pro-adipogenic tf, and enhances expression of klf2 and klf3, which are anti-adipogenic. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KLF2
- 
- 