| + |
GSK3B | down-regulates activity 
phosphorylation
|
DPYSL2 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133251 |
Ser518 |
KTVTPASsAKTSPAK |
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 15652488 |
Ser-518 is also a potential phosphorylation site of CRMP-2 by GSK-3_. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264839 |
Thr509 |
PVCEVSVtPKTVTPA |
Homo sapiens |
|
| pmid |
sentence |
| 25040932 |
Cdk5 and DYRK2 phosphorylate CRMP2 and CRMP4, respectively, priming these proteins at S522 before their subsequent phosphorylation by GSK-3b at T509, T516 and S518|e CRMP2 phosphorylation by GSK-3b disrupts its interaction with tubulin (Yamashita & Goshima, 2012), leading to growth inhibition |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133255 |
Thr514 |
SVTPKTVtPASSAKT |
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 15652488 |
Here, we showed that glycogen synthase kinase-3beta (gsk-3beta) phosphorylated crmp-2 at thr-514 and inactivated it |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264840 |
Thr514 |
SVTPKTVtPASSAKT |
Homo sapiens |
|
| pmid |
sentence |
| 25040932 |
Cdk5 and DYRK2 phosphorylate CRMP2 and CRMP4, respectively, priming these proteins at S522 before their subsequent phosphorylation by GSK-3b at T509, T516 and S518|e CRMP2 phosphorylation by GSK-3b disrupts its interaction with tubulin (Yamashita & Goshima, 2012), leading to growth inhibition |
|
| Publications: |
4 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| + |
CDK5 | down-regulates activity
phosphorylation
|
DPYSL2 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264838 |
Ser522 |
PASSAKTsPAKQQAP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25040932 |
Cdk5 and DYRK2 phosphorylate CRMP2 and CRMP4, respectively, priming these proteins at S522 before their subsequent phosphorylation by GSK-3b at T509, T516 and S518|e CRMP2 phosphorylation by GSK-3b disrupts its interaction with tubulin (Yamashita & Goshima, 2012), leading to growth inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROCK1 |
phosphorylation
|
DPYSL2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249042 |
Thr555 |
DNIPRRTtQRIVAPP |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 10818093 |
We produced an antibody that specifically recognizes CRMP-2 phosphorylated at Thr-555. Using this antibody, we found that Rho-kinase phosphorylated CRMP-2 downstream of Rho in COS7 cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
ROCK2 | up-regulates 
phosphorylation
|
DPYSL2 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77543 |
Thr555 |
DNIPRRTtQRIVAPP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10818093 |
Rho-kinase phosphorylated crmp-2 at thr-555 in vitro.we demonstrated that crmp-2 is phosphorylated by rho-kinase in drg neurons during lpa-induced growth cone collapse. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPYSL2 | up-regulates 
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264841 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25040932 |
In the non-phosphorylated state, CRMP2 binding to tubulin induces the promotion of tubulin polymerisation leading to dendrite outgrowth while |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPYSL2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264842 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25040932 |
In the non-phosphorylated state, CRMP2 binding to tubulin induces the promotion of tubulin polymerisation leading to dendrite outgrowth while |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DPYSL2
- 
- 