| + |
PRKACA | up-regulates activity 
phosphorylation
|
AANAT |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250324 |
Ser205 |
HPFLRRNsGC |
in vitro |
|
| pmid |
sentence |
| 11336675 |
AANAT1–207 was phosphorylated in vitro at both PKA sites, Thr-31 and Ser-205. regulation is achieved by binding to 14-3-3, which structurally modulates the substrate binding sites, leading to measurable effects on the affinity of AANAT for its substrates with an accompanying increase in activity at low substrate concentrations. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250325 |
Thr31 |
PSCQRRHtLPASEFR |
in vitro |
|
| pmid |
sentence |
| 11336675 |
AANAT1201 is phosphorylated at Thr-31 by PKA, it binds to 14-3-3. regulation is achieved by binding to 14-3-3, which structurally modulates the substrate binding sites, leading to measurable effects on the affinity of AANAT for its substrates with an accompanying increase in activity at low substrate concentrations. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
AANAT | up-regulates quantity
chemical modification
|
N-acetylserotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265478 |
|
|
in vitro |
|
| pmid |
sentence |
| 22775292 |
Here, we present the X-ray crystal structure of human N-acetyl serotonin methyltransferase (ASMT), the last enzyme of the melatonin biosynthesis pathway. Melatonin synthesis requires serotonin, which is first acetylated by the arylalkylamine N-acetyltransferase (AA-NAT) to produce N-acetyl serotonin (NAS) (Fig. 1A). Then, acetyl serotonin methyltransferase (ASMT, also known as hydroxyindole O-methyltransferase or HIOMT) produces melatonin by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to NAS. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
serotonin | up-regulates activity
chemical activation
|
AANAT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265477 |
|
|
in vitro |
|
| pmid |
sentence |
| 22775292 |
Here, we present the X-ray crystal structure of human N-acetyl serotonin methyltransferase (ASMT), the last enzyme of the melatonin biosynthesis pathway. Melatonin synthesis requires serotonin, which is first acetylated by the arylalkylamine N-acetyltransferase (AA-NAT) to produce N-acetyl serotonin (NAS) (Fig. 1A). Then, acetyl serotonin methyltransferase (ASMT, also known as hydroxyindole O-methyltransferase or HIOMT) produces melatonin by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to NAS. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
AANAT
- 
- 