+ |
RPS6K | up-regulates activity
phosphorylation
|
PPP1R3A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252777 |
Ser46 |
PQPSRRGsDSSEDIY |
in vitro |
|
pmid |
sentence |
10648825 |
The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasmic reticulum (SR) of striated muscles, is known to be phosphorylated at Ser48 and Ser67 in vitro by adenosine 3',5' cyclic monophosphate-dependent protein kinase (PKA) and at Ser48 by MAP kinase-activated protein kinase-1 (MAPKAP-K1, also called p90 RSK). The phosphorylation of Ser48 increases the rate at which the glycogen-associated PP1.G(M) complex dephosphorylates (activates) glycogen synthase, but the phosphorylation of Ser67 has the opposite effect, suppressing the activity of PP1 toward glycogen-bound substrates. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
RPS6KA1 | up-regulates activity
phosphorylation
|
PPP1R3A |
0.416 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249036 |
Ser46 |
PQPSRRGsDSSEDIY |
in vitro |
|
pmid |
sentence |
10648825 |
The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasmic reticulum (SR) of striated muscles, is known to be phosphorylated at Ser48 and Ser67 in vitro by adenosine 3',5' cyclic monophosphate-dependent protein kinase (PKA) and at Ser48 by MAP kinase-activated protein kinase-1 (MAPKAP-K1, also called p90 RSK). The phosphorylation of Ser48 increases the rate at which the glycogen-associated PP1.G(M) complex dephosphorylates (activates) glycogen synthase, but the phosphorylation of Ser67 has the opposite effect, suppressing the activity of PP1 toward glycogen-bound substrates. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
PPP1R3A | up-regulates
dephosphorylation
|
GYS1 |
0.493 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-37301 |
|
|
Homo sapiens |
|
pmid |
sentence |
8250835 |
In skeletal muscle, the activation of glycogen synthase by insulin involves the dephosphorylation of serine residues that are phosphorylated by gsk3 and dephosphorylated by the glycogen-associated form of protein phosphatase-l (pp1g). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Muscle, Skeletal Muscle |