Relation Results

Summary

Name RPS6KA1
Full Name Ribosomal protein S6 kinase alpha-1
Synonyms S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1 | MAPKAPK1A, RSK1
Primary ID Q15418
Links - -
Type protein
Relations 87
Pathways AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation ...
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Type: Score: Layout: SPV 
0.5530.20.4920.4010.7420.3230.3180.5030.20.7630.3540.3570.3890.7520.620.20.710.20.6010.250.3270.5020.3720.2550.5390.5230.3180.4160.540.2910.4210.3350.4610.5580.2880.3630.340.3350.340.4580.20.20.3640.7170.3630.70.20.20.467RPS6KA1YBX1H3-3AL1CAMBADCREB1RANBP3MXD1ESR1CICTSC2ETV1OSTF1FLNAMAPK1PDPK1MAPK3ERK1/2RPS6CCT2METTL1DEPTORCDC25ACDC25BFOSEEF2KNR4A3MITFEIF4BSTK11PPP1R3ACARHSP1SLC9A1RPTORMAGI1GSK3BWWC1SLC9A3R1CDC34VASPSENP2LTN1IRS1TSCTP53Translational_regulationGbetaHistone H3mTORC1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation YBX1 0.553
Identifier Residue Sequence Organism Cell Line
SIGNOR-182497 Ser102 NPRKYLRsVGDGETV Homo sapiens Breast Cancer Cell
pmid sentence
We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-119221 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-138467 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70428 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 3 Organism: Homo Sapiens
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation L1CAM 0.492
Identifier Residue Sequence Organism Cell Line
SIGNOR-248948 Ser1152 RSKGGKYsVKDKEDT Rattus norvegicus PC-12 Cell
pmid sentence
Western blot analysis demonstrated that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk). Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 from brain, and metabolic labeling studies have demonstrated that Ser1152 is phosphorylated in vivo in the developing rat brain. | These data demonstrate that the membrane-proximal 15 amino acids of the cytoplasmic domain of L1 are important for neurite outgrowth on L1, and the interactions it mediates may be regulated by phosphorylation of Ser1152.
Publications: 1 Organism: Rattus Norvegicus
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.401
Identifier Residue Sequence Organism Cell Line
SIGNOR-78020 Ser118 GRELRRMsDEFVDSF Homo sapiens HEK-293 Cell
pmid sentence
Rsk1, and survival factor signaling stimulate phosphorylation of bad at ser-155, blocking the binding of bad to bcl-xl.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249045 Ser153 SWTRVFQsWWDRNLG Homo sapiens HEK-293 Cell
pmid sentence
We report here that the phosphorylation of BAD at Ser-155 within the BH3 domain is a second phosphorylation-dependent mechanism that inhibits the death-promoting activity of BAD. Protein kinase A, RSK1, and survival factor signaling stimulate phosphorylation of BAD at Ser-155, blocking the binding of BAD to Bcl-XL. RSK1 phosphorylates BAD at both Ser-112 and Ser-155 and rescues BAD-mediated cell death in a manner dependent upon phosphorylation at both sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-160635 Ser75 EIRSRHSsYPAGTED Homo sapiens Melanoma Cell
pmid sentence
To understand the mechanisms underlying B-RAF effects on cell survival we initially analysed the Bcl-2 family protein, Bad, that is phosphorylated by RSK1 at the inhibitory serine-75 residue in a MEK-dependent manner in melanoma cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-180910 Ser75 EIRSRHSsYPAGTED Homo sapiens HEK-293 Cell
pmid sentence
The rsks catalyze the phosphorylation of the pro-apoptotic protein bad at serine 112 to promote cell survival.
Publications: 4 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Inhibition of Apoptosis
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation CREB1 0.742
Identifier Residue Sequence Organism Cell Line
SIGNOR-72117 Ser119 EILSRRPsYRKILND Homo sapiens
pmid sentence
The rsks phosphorylate the trascription factor creb at serine 133 to promote cell survival.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis
+ RPS6KA1 img/unknown.png phosphorylation RANBP3 0.323
Identifier Residue Sequence Organism Cell Line
SIGNOR-160904 Ser126 VKRERTSsLTQFPPS Homo sapiens
pmid sentence
Rsk phosphorylates serine 58 of ranbp3 in vitro and in vivo
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation MXD1 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-178586 Ser145 IERIRMDsIGSTVSS Homo sapiens
pmid sentence
In this study, we showed that mad1 is a substrate of p90 ribosomal kinase (rsk) and p70 s6 kinase (s6k). Both rsk and s6k phosphorylate serine 145 of mad1 upon serum or insulin stimulation. Ser-145 phosphorylation of mad1 accelerates the ubiquitination and degradation of mad1 through the 26s proteasome pathway
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation ESR1 0.503
Identifier Residue Sequence Organism Cell Line
SIGNOR-34113 Ser167 GGRERLAsTNDKGSM Homo sapiens Breast Cancer Cell
pmid sentence
Serine 167 is the major phosphorylation site on the human estrogen receptor. Phosphorylation is mediated by casein kinase ii.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation CIC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-169883 Ser173 PGKRRTQsLSALPKE Homo sapiens Melanoma Cell
pmid sentence
Specifically, 14-3-3 binds to p90(rsk)-phosphorylated ser?_??_ Of capic?_A thereby modulating dna binding to its hmg (high-mobility group) box, whereas erk phosphorylations prevent binding of a c-terminal nls (nuclear localization sequence) to importin ?4 (kpna3)
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation TSC2 0.763
Identifier Residue Sequence Organism Cell Line
SIGNOR-128634 Ser1798 GQRKRLIsSVEDFTE Homo sapiens HEK-293 Cell
pmid sentence
The mitogen-activated protein kinase (mapk)-activated kinase, p90 ribosomal s6 kinase (rsk) 1, was found to interact with and phosphorylate tuberin at a regulatory site, ser-1798, located at the evolutionarily conserved c terminus of tuberin. Rsk1 phosphorylation of ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mtor signaling to s6k1
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation ETV1 0.354
Identifier Residue Sequence Organism Cell Line
SIGNOR-249162 Ser191 HRFRRQLsEPCNSFP Homo sapiens
pmid sentence
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249163 Ser216 PMYQRQMsEPNIPFP Homo sapiens
pmid sentence
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation OSTF1 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-273838 Ser202 TDAVRTLsNAEDYLD Homo sapiens HeLa Cell
pmid sentence
SH3P2 was phosphorylated on Ser(202) by ribosomal S6 kinase (RSK) in an ERK pathway-dependent manner, and such phosphorylation inhibited the ability of SH3P2 to suppress cell motility. 
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation FLNA 0.389
Identifier Residue Sequence Organism Cell Line
SIGNOR-123458 Ser2152 TRRRRAPsVANVGSH Homo sapiens Melanoma Cell
pmid sentence
We show that the n-terminal kinase domain of rsk phosphorylates flna on ser(2152) in response to mitogens
Publications: 1 Organism: Homo Sapiens
+ MAPK1up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.752
Identifier Residue Sequence Organism Cell Line
SIGNOR-219308 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219312 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219316 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219320 Ser732 RRVRKLPsTTL Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219324 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219328 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-59363 Thr573 AENGLLMtPCYTANF Homo sapiens HeLa Cell
pmid sentence
Thus, MAPK1/ERK1 and MAPK2/ERK2 activate three closely related protein kinases known as MAPK_activated protein kinases_1a, _1b and _1c (MAPKAP_K1a/b/c; also known as RSK1/2/3)
Identifier Residue Sequence Organism Cell Line
SIGNOR-102645 Homo sapiens
pmid sentence
Efficient rsk activation by erk requires its interaction through a docking site located near the c terminus of rsk
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ PDPK1up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.62
Identifier Residue Sequence Organism Cell Line
SIGNOR-250270 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS-7 Cell
pmid sentence
Full-length RSK1, RSK2, and RSK3 Are Activated when Coexpressed with PDK1 in COS7 Cells. Ser221 phosphorylation is increased 2–3-fold during ERK-mediated activation of RSK1 in COS1 cells
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, FLT3-ITD signaling, MTOR Signaling
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-162681 Ser221 DHEKKAYsFCGTVEY Homo sapiens HEK-293 Cell
pmid sentence
Herein, we demonstrate that the n-terminal kinase domain (ntk) of rsk1 is necessary for interactions with pkarialpha. Substitution of the activation loop phosphorylation site (ser-221) in the ntk with the negatively charged asp residue abrogated the association between rsk1 and pkarialpha.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
+ MAPK3up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.71
Identifier Residue Sequence Organism Cell Line
SIGNOR-219332 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219337 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219341 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219345 Ser732 RRVRKLPsTTL Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219349 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-219353 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-102648 Homo sapiens
pmid sentence
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Identifier Residue Sequence Organism Cell Line
SIGNOR-38999 Mus musculus
pmid sentence
The pp90rsk phosphothreonine content paralleled the ERK1 activity more closely than the phosphoserine level. These results provide compelling evidence that in fibroblasts and PC12 cells ERK1 plays a direct role in the phosphorylation of pp90rsk and that pp90rsk represents a physiologically relevant substrate of extracellular-regulated kinases
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-250553 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250554 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250555 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250556 Ser732 RRVRKLPsTTL Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250557 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250558 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation RPS6 0.601
Identifier Residue Sequence Organism Cell Line
SIGNOR-153618 Ser235 IAKRRRLsSLRASTS Homo sapiens
pmid sentence
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism.
Identifier Residue Sequence Organism Cell Line
SIGNOR-153622 Ser236 AKRRRLSsLRASTSK Homo sapiens
pmid sentence
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism.
Identifier Residue Sequence Organism Cell Line
SIGNOR-171243 Ser240 RLSSLRAsTSKSESS Homo sapiens
pmid sentence
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-171247 Ser244 LRASTSKsESSQK Homo sapiens
pmid sentence
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity
Publications: 4 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation CCT2 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-172986 Ser260 GSRVRVDsTAKVAEI Homo sapiens
pmid sentence
Furthermore, both the s260a and s260d mutants showed a decreased folding capacity as compared to cells expressing the wild-type cct_ subunit ( fig.?_5e), suggesting that a cyclic phosphorylation of the s260 site by s6k1 is likely to be important for chaperonin function and that mutation of this site interferes with this process.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation METTL1 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-135948 Ser27 YYRQRAHsNPMADHT Homo sapiens HEK-293 Cell, HeLa Cell
pmid sentence
Pkb and ribosomal s6 kinase (rsk) both phosphorylated mettl1 at ser27 in vitro.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation DEPTOR 0.502
Identifier Residue Sequence Organism Cell Line
SIGNOR-176883 Ser286 SSMSSCGsSGYFSSS Homo sapiens
pmid sentence
We found that deptor was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the f box protein _trcp, with consequent proteasomal degradation of deptor. Phosphorylation of the _trcp degron in deptor is executed by ck1
Identifier Residue Sequence Organism Cell Line
SIGNOR-176887 Ser287 SMSSCGSsGYFSSSP Homo sapiens
pmid sentence
We found that deptor was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the f box protein _trcp, with consequent proteasomal degradation of deptor. Phosphorylation of the _trcp degron in deptor is executed by ck1
Identifier Residue Sequence Organism Cell Line
SIGNOR-176891 Ser291 CGSSGYFsSSPTLSS Homo sapiens
pmid sentence
We found that deptor was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the f box protein _trcp, with consequent proteasomal degradation of deptor. Phosphorylation of the _trcp degron in deptor is executed by ck1
Publications: 3 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation CDC25A 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-202113 Ser293 GSTKRRKsMSGASPK Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Identifier Residue Sequence Organism Cell Line
SIGNOR-202117 Ser295 TKRRKSMsGASPKES Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation CDC25B 0.255
Identifier Residue Sequence Organism Cell Line
SIGNOR-202121 Ser353 VQNKRRRsVTPPEEQ Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Identifier Residue Sequence Organism Cell Line
SIGNOR-202125 Thr355 NKRRRSVtPPEEQQE Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation FOS 0.539
Identifier Residue Sequence Organism Cell Line
SIGNOR-37154 Ser362 AAAHRKGsSSNEPSS Homo sapiens
pmid sentence
We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kda ribosomal s6 kinase (rsk) and mitogen-activated protein kinase (map kinase), contribute to the serum-induced phosphorylation of c-fos. The major phosphopeptides derived from biosynthetically labeled c-fos correspond to phosphopeptides generated after phosphorylation of c-fos in vitro with both rsk and map kinase. The phosphorylation sites identified for rsk (ser-362) and map kinase (ser-374) are in the transrepression domain. Cooperative phosphorylation at these sites by both enzymes was observed in vitro and reflected in vivo by the predominance of the peptide phosphorylated on both sites, as opposed to singly phosphorylated peptides. This study suggests a role for nuclear rsk and map kinase in modulating newly synthesized c-fos phosphorylation and downstream signaling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262999 Ser374 PSSDSLSsPTLLAL
pmid sentence
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos
Publications: 2 Organism: Homo Sapiens,
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.523
Identifier Residue Sequence Organism Cell Line
SIGNOR-109708 Ser366 SPQVRTLsGSRPPLL Homo sapiens Embryonic Cell Line
pmid sentence
We show that two such kinases, p70 s6 kinase (regulated via mtor) and p90(rsk1) (activated by erk), phosphorylate eef2k at a conserved serine and inhibit its activity
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1 img/unknown.png phosphorylation NR4A3 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-249297 Ser376 GRRGRLPsKPKSPLQ Homo sapiens HEK-293 Cell
pmid sentence
We have established that two related proteins, Nurr1 and Nor1, are also phosphorylated on the equivalent site by RSK in cells in response to mitogenic stimulation. | Similar to Nur77, when FLAG€“Nor1 was expressed in HEK-293 cells, its phosphorylation on Ser377 was stimulated by both PMA and EGF
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation MITF 0.416
Identifier Residue Sequence Organism Cell Line
SIGNOR-75034 Ser409 HGLSLIPsTGLCSPD Homo sapiens
pmid sentence
The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73, whereas serine 409 serves as a substrate for p90 rsk-1. An unphosphorylatable double mutant at these two residues is at once profoundly stable and transcriptionally inert.
Identifier Residue Sequence Organism Cell Line
SIGNOR-174760 Ser409 HGLSLIPsTGLCSPD Homo sapiens
pmid sentence
The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73, whereas serine 409 serves as a substrate for p90 rsk-1. An unphosphorylatable double mutant at these two residues is at once profoundly stable and transcriptionally inert.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation EIF4B 0.54
Identifier Residue Sequence Organism Cell Line
SIGNOR-123993 Ser422 RERSRTGsESSQTGT Homo sapiens
pmid sentence
S6k1/s6k2 specifically phosphorylate ser422 in vitro. Substitution of ser422 with ala results in a loss of activity in an in vivo translation assay, indicating that phosphorylation of this site plays an important role in eif4b function.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.291
Identifier Residue Sequence Organism Cell Line
SIGNOR-209871 Ser428 SSKIRRLsACKQQ Homo sapiens Leukemia Cell
pmid sentence
Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cellsBRAFV600E activates downstream molecules, including ERK and p90 ribosomal S6 kinase (RSK), and leads to the phosphorylation of LKB-1 at Ser428 by these kinases. This cascade results in the dissociation of LKB1 from AMPK.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation PPP1R3A 0.421
Identifier Residue Sequence Organism Cell Line
SIGNOR-249036 Ser46 PQPSRRGsDSSEDIY in vitro
pmid sentence
The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasmic reticulum (SR) of striated muscles, is known to be phosphorylated at Ser48 and Ser67 in vitro by adenosine 3',5' cyclic monophosphate-dependent protein kinase (PKA) and at Ser48 by MAP kinase-activated protein kinase-1 (MAPKAP-K1, also called p90 RSK). The phosphorylation of Ser48 increases the rate at which the glycogen-associated PP1.G(M) complex dephosphorylates (activates) glycogen synthase, but the phosphorylation of Ser67 has the opposite effect, suppressing the activity of PP1 toward glycogen-bound substrates. 
Publications: 1 Organism: In Vitro
+ RPS6KA1 img/unknown.png phosphorylation CARHSP1 0.335
Identifier Residue Sequence Organism Cell Line
SIGNOR-137482 Ser52 TRRTRTFsATVRASQ Homo sapiens
pmid sentence
These and other results demonstrate that crhsp24 is phosphorylated at ser52 by pkbalpha in response to igf-1, at ser52 by pkbalpha and rsk in response to egf
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ RPS6KA1up-regulates quantity img/direct-activation.png phosphorylation RANBP3 0.323
Identifier Residue Sequence Organism Cell Line
SIGNOR-276149 Ser57 HGTGHPEsAGEHALE Homo sapiens HEK-293 Cell
pmid sentence
RSK phosphorylates RanBP3 at Serine 58 residue in vitro and in vivo.RanBP3 phosphorylation increases its affinity towards Ran
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation SLC9A1 0.461
Identifier Residue Sequence Organism Cell Line
SIGNOR-69171 Ser703 MSRARIGsDPLAYEP Homo sapiens
pmid sentence
The results indicate that p90rsk phosphorylates serine 703 of nhe-1, and this phosphorylation is required for growth factor stimulation of na+/h+ exchange.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation RPTOR 0.558
Identifier Residue Sequence Organism Cell Line
SIGNOR-180458 Ser719 PCTPRLRsVSSYGNI Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-180462 Ser721 TPRLRSVsSYGNIRA Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-180466 Ser722 PRLRSVSsYGNIRAV Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Publications: 3 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation MAGI1 0.288
Identifier Residue Sequence Organism Cell Line
SIGNOR-273837 Ser741 QPLERKDsQNSSQHS Homo sapiens HUVEC Cell
pmid sentence
 We report herein that p90RSK associates with MAGI1 in ECs and executes 2 independently regulated PTMs of MAGI1: S741 phosphorylation and K931 deSUMOylation. MAGI1-S741 phosphorylation is vital for Rap1 activation.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.363
Identifier Residue Sequence Organism Cell Line
SIGNOR-110917 Ser9 SGRPRTTsFAESCKP Homo sapiens
pmid sentence
S6k then phosphorylates the same serine residue on gsk3 that is targeted by pkb/akt (fig. 1), thereby inhibiting its activity.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, MTOR Signaling
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation WWC1 0.34
Identifier Residue Sequence Organism Cell Line
SIGNOR-203294 Ser947 CRLNRSDsDSSTLSK Homo sapiens
pmid sentence
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. erk_rsk phosphorylation of kibra is required for proper cell proliferation and rsk-mediated phosphorylation also positively modulates kibra's migratory activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-203298 Thr929 STIIRSKtFSPGPQS Homo sapiens
pmid sentence
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2.
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ RPS6KA1up-regulates activity img/direct-activation.png phosphorylation SLC9A3R1 0.335
Identifier Residue Sequence Organism Cell Line
SIGNOR-278290 Thr156 ELRPRLCtMKKGPSG Homo sapiens
pmid sentence
In summary, these results demonstrate that Ras-RSK1 signaling promotes nuclear localization of EBP50.|Specifically, RSK1 phosphorylates EBP50 at threonine 156 (T156) residue in a cell cycle dependent manner, which is important for nuclear translocation of EBP50 to facilitate cellular proliferation and transformation.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDC34 0.34
Identifier Residue Sequence Organism Cell Line
SIGNOR-277330 Thr162 KGKDREYtDIIRKQV in vitro
pmid sentence
RSK1 phosphorylated Thr162 on UBE2R1.RSK1 induced self-ubiquitination and destabilisation of UBE2R1 by phosphorylation.
Publications: 1 Organism: In Vitro
+ RPS6KA1down-regulates img/direct_inhibition.png phosphorylation VASP 0.458
Identifier Residue Sequence Organism Cell Line
SIGNOR-172899 Thr278 LARRRKAtQVGEKTP Homo sapiens Lung Cancer Cell
pmid sentence
Rsk1 phosphorylated vasp on t278, a site regulating its binding to actin.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation SENP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273839 Thr369 TDDLLELtEDMEKEI Homo sapiens HUVEC Cell
pmid sentence
 Here, we determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosphorylated threonine 368 (T368) of SENP2. T368 phosphorylation promoted nuclear export of SENP2, leading to downregulation of eNOS expression and upregulation of proinflammatory adhesion molecule expression and apoptosis. 
Publications: 1 Organism: Homo Sapiens
+ LTN1down-regulates activity img/direct_inhibition.png ubiquitination RPS6KA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278757 Homo sapiens
pmid sentence
Ltn1 ubiquitylation of RSK1, RSK2, and TWY3 could either result in degradation or impart a regulatory function on target proteins distinct from degradation.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.364
Identifier Residue Sequence Organism Cell Line
SIGNOR-175687 Homo sapiens
pmid sentence
Negative feedback involves s6k, which inactivates irs by phosphorylation at multiple sites, thus inducing its degradation and altered cell localization.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:AMPK Signaling, MTOR Signaling
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation TSC 0.717
Identifier Residue Sequence Organism Cell Line
SIGNOR-217900 Homo sapiens HEK-293 Cell
pmid sentence
The mitogen-activated protein kinase (mapk)-activated kinase, p90 ribosomal s6 kinase (rsk) 1, was found to interact with and phosphorylate tuberin at a regulatory site, ser-1798, located at the evolutionarily conserved c terminus of tuberin. Rsk1 phosphorylation of ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mtor signaling to s6k1
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, MTOR Signaling
+ TP53up-regulates img/indirect-activation.png RPS6KA1 0.363
Identifier Residue Sequence Organism Cell Line
SIGNOR-124038 Homo sapiens
pmid sentence
Rather, p53 expression stimulates the serine/threonine kinase ribosomal s6 kinase 1 (rsk1), which in turn phosphorylates the p65 subunit of nf-kb.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ RPS6KA1up-regulates img/indirect-activation.png Translational_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268528 Homo sapiens
pmid sentence
Mutation of rpS6 at Ser(235/236) reveals that phosphorylation of these sites promotes its recruitment to the 7-methylguanosine cap complex, suggesting that Ras/ERK signaling regulates assembly of the translation preinitiation complex. These data demonstrate that RSK provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery.
Publications: 1 Organism: Homo Sapiens
+ Gbetaup-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270002 Mus musculus Neuron
pmid sentence
The pp90rsk phosphothreonine content paralleled the ERK1 activity more closely than the phosphoserine level. These results provide compelling evidence that in fibroblasts and PC12 cells ERK1 plays a direct role in the phosphorylation of pp90rsk and that pp90rsk represents a physiologically relevant substrate of extracellular-regulated kinases
Publications: 1 Organism: Mus Musculus
+ RPS6KA1down-regulates activity img/direct_inhibition.png phosphorylation Histone H3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265346 Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation mTORC1 0.467
Identifier Residue Sequence Organism Cell Line
SIGNOR-217553 Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
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