3.0
Summary
| Name |  LTC4SView Modifications |
| Full Name | Leukotriene C4 synthase |
| Synonyms | LTC4 synthase, Leukotriene-C(4) synthase | |
| Primary ID | Q16873 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RPS6KB1 | down-regulates activity 
phosphorylation
|
LTC4S | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | LTC4S | down-regulates quantity
chemical modification
|
leukotriene A4(1-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LTC4S | down-regulates quantity
chemical modification
|
glutathionate(1-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NfKb-p65/p50 | down-regulates quantity by repression 
transcriptional regulation
|
LTC4S | 0.26 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LTC4S | up-regulates quantity 
chemical modification
|
leukotriene C4(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |