3.0
Summary
| Name |  ZNF423
|
| Full Name | Zinc finger protein 423 |
| Synonyms | Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein | KIAA0760, NPHP14, OAZ |
| Primary ID | Q2M1K9 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | FAP: miRNA and adipogensis |
| Function | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |
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post transcriptional regulation