| + |
FOXO1 | down-regulates 
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178281 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18423396 |
Akt1/Pkb-alpha was found to be the major regulator of phosphorylation and nuclear export of Foxo1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254973 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
Constitutively active Foxo1 prevents the differentiation of preadipocytes, while dominant-negative Foxo1 restores adipocyte differentiation of fibroblasts from insulin receptor-deficient mice. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254981 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
�The present data provide a direct link between insulin signaling through Irs _ PI 3-kinase _ Akt and adipogenesis through Foxo1 phosphorylation. Inhibition of Foxo1 via phosphorylation appears to be required during the clonal expansion phase, and our data show that unrestrained Foxo1 activity prevents terminal differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254977 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
�The present data provide a direct link between insulin signaling through Irs _ PI 3-kinase _ Akt and adipogenesis through Foxo1 phosphorylation. Inhibition of Foxo1 via phosphorylation appears to be required during the clonal expansion phase, and our data show that unrestrained Foxo1 activity prevents terminal differentiation. |
|
| Publications: |
4 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling |
| + |
GATA2 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78659 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11021798 |
Constitutive gata-2 and gata-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Thyroid Hormone Metabolism |
| + |
FOXO | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423396 |
Akt1/pkbalpha was found to be the major regulator of phosphorylation and nuclear export offoxo1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
KDM2B | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252243 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
Here, we show that FBXL10/KDM2B is an anti-adipogenic factor that is up-regulated during the early phase of 3T3-L1 preadipocyte differentiation and in adipose tissue in a diet-induced model of obesity. These results suggest that FBXL10 represses adipogenesis by targeting a noncanonical PRC1 complex to repress key genes (e.g. Pparg) that control conversion of pluripotent cells into the adipogenic lineage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPB | up-regulates 
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238297 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25451943 |
Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) β plays an essential role. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250564 |
|
|
|
|
| pmid |
sentence |
| 11884404 |
Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, |
| Pathways: | Adipogenesis |
| + |
DLK1 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197634 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22640926 |
We conclude that DLK1(PREF1) is well expressed in human ASC and acts as a negative regulator of adipogenesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254980 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8500166 |
This indicates that pref-1 functions as a negative regulator of adipocyte differentiation, possibly in a manner analogous to EGF-like proteins that govern cell fate decisions in invertebrates. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | FAP: Insulin-mediated adipogenesis |
| + |
KLF15 | up-regulates
transcriptional regulation
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236230 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 20956975 |
Our results provide a new mechanism for understanding glucocorticoids-dependent adipogenesis and that GR promotes adipogenesis via KLF15 gene expression as a transcriptional direct target. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT10B | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
We have identified wnt10b as a potent inhibitor of adipogenesis that must be suppressed for preadipocytes to differentiate in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173421 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21514273 |
Tumor necrosis factor-? (TNF-alpha) Is known to suppress adipocyte differentiation via a Beta-catenin-dependent pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling, Thyroid Hormone Metabolism |
| + |
HES1 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253058 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16282371 |
Notch signaling blocks differentiation of 3T3-L1 preadipocytes, and this can be mimicked by constitutive expression of the Notch target gene Hes-1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARG | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228622 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16150867 |
Adipocyte differentiation is regulated largely through the actions of the peroxisome proliferator-activated receptor (PPAR) gamma nuclear receptor |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256229 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16150867 |
Adipocyte differentiation is regulated largely through the actions of the peroxisome proliferator-activated receptor (PPAR) gamma nuclear receptor |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Mammary Epithelial Cell |
| Pathways: | Adipogenesis, Circadian clock, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling, PPARgamma in cancer |
| + |
NR3C1/STAT5A | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12540601 |
We have shown that stat5a is associated with the glucocorticoid receptor during adipogenesis in a highly regulated manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
MMP14 | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255909 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 28709001 |
MMP14 Promotes Adipogenesis Downstream of or in Parallel to TIMP3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPA | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132946 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17139329 |
C/EBPα induces many adipocyte genes directly, and in vivo studies indicate an important role for this factor in the development of adipose tissue. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250562 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25451943 |
Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) ² plays an essential role. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
NOC3L | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253060 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 15564382 |
Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
mTORC1 | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235349 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19593385 |
Activation of mTORC1 causes a robust increase in the mRNA and protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma), which is the master transcriptional regulator of adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Thyroid Hormone Metabolism |
| + |
STAT5A | up-regulates
transcriptional regulation
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12540601 |
We have shown that stat5a is associated with the glucocorticoid receptor during adipogenesis in a highly regulated manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling, Leptin Signaling |
| + |
Noncanonical PRC1 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252248 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We show that FBXL10/KDM2B is an anti-adipogenic factor that is up-regulated during the early phase of 3T3-L1 preadipocyte differentiation and in adipose tissue in a diet-induced model of obesity. Interestingly, inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA3 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78830 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11021798 |
Constitutive gata-2 and gata-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ZNF423 | up-regulates activity
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255928 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 20200519 |
Ectopic expression of Zfp423 in non-adipogenic NIH 3T3 fibroblasts robustly activates expression of Pparg in undifferentiated cells and permits cells to undergo adipocyte differentiation under permissive conditions. Short hairpin RNA (shRNA)-mediated reduction of Zfp423 expression in 3T3-L1 cells blunts preadipocyte Pparg expression and diminishes the ability of these cells to differentiate. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TIMP3 | down-regulates activity
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255906 |
|
|
Mus musculus |
Muscle Stem Cell |
| pmid |
sentence |
| 28709001 |
Hh signaling through FAP cilia regulated the expression of TIMP3, a secreted metalloproteinase inhibitor, that inhibited MMP14 to block adipogenesis. A pharmacological mimetic of TIMP3 blocked the conversion of FAPs into adipocytes |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF6 | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137807 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15917248 |
We have identified kr?ppel-like factor-6 (klf6), a recently described tumor suppressor gene, as a repressor of the proto-oncogene delta-like 1 (dlk1), a gene encoding a transmembrane protein that inhibits adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1D1 | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268023 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12821652 |
Mutations of the 5' or 3' half-sites of the response element totally abrogated PPARgamma binding and transcriptional activation, identifying this site as a novel type of functional PPARgamma response element. Finally, ectopic expression of Rev-Erbalpha in 3T3-L1 preadipocytes potentiated adipocyte differentiation induced by the PPARgamma ligand rosiglitazone. These results identify Rev-Erbalpha as a target gene of PPARgamma in adipose tissue and demonstrate a role for this nuclear receptor as a promoter of adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
ANKRD26 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266071 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21669876 |
Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TCF7L2 | down-regulates activity
transcriptional regulation
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253519 |
|
|
|
|
| pmid |
sentence |
| 20492721 |
These findings suggested that miR-210 could promote adipogenesis by repressing WNT signaling through targeting Tcf7l2. |
|
| Publications: |
1 |
| + |
CCND1 | down-regulates activity
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258981 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15713663 |
Collectively, these studies suggest an important role of cyclin D1 in regulation of PPARgamma-mediated adipocyte differentiation through recruitment of HDACs to regulate PPAR response element local chromatin structure and PPARgamma function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LMNA | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45455 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 16415042 |
Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy.|We conclude that A-type lamins act as inhibitors of adipocyte differentiation, possibly by affecting PPARgamma2 and insulin signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IGF1 | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2689937 |
Preadipocytes converted to adipocytes when insulin-like growth factor-1 or insulin was added to a medium depleted of those compounds |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Adipogenesis