Summary

Name SLC4A8
Full Name Electroneutral sodium bicarbonate exchanger 1
Synonyms Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3 | KIAA0739, NBC, NBC3, NDCBE1
Primary ID Q2Y0W8
Links - -
Type protein
Relations 1
Function Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png relocalization hydrogencarbonate 0.8
Publications: 1 Organism: Homo Sapiens