3.0
Summary
| Name |  SLC4A8
|
| Full Name | Electroneutral sodium bicarbonate exchanger 1 |
| Synonyms | Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3 | KIAA0739, NBC, NBC3, NDCBE1 |
| Primary ID | Q2Y0W8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SLC4A8 | up-regulates quantity 
relocalization
|
hydrogencarbonate | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |