| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265479 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 32376282 |
HYDIN promotes expression of Gata4 in cardiomyocyte differentiation. HYDIN functions as a positive regulator of human cardiomyocyte differentiation and promotes expression of cardiac contractile genes in hESC cells. This is mediated through GATA4, a critical transcription factor in heart development. Cardiac-specific Hydin knockdown in vivo leads to Gata4 downregulation and enhanced atrial septal defect (ASD) risk in mice. GATA4 is a fundamental TF in embryonic heart development and cardiac differentiation, and reduction in GATA4 function results in a diverse range of CHDs |
|
HYDIN
- 
- 
3.0
transcriptional regulation