3.0
Summary
| Name |  PARP10View Modifications |
| Full Name | Protein mono-ADP-ribosyltransferase PARP10 |
| Synonyms | EC 2.4.2.-, ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, Poly [ADP-ribose] polymerase 10, PARP-10 | |
| Primary ID | Q53GL7 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinE/CDK2 | up-regulates activity 
phosphorylation
|
PARP10 | 0.305 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PLK1 | up-regulates activity
phosphorylation
|
PARP10 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PARP10 | up-regulates activity
post translational modification
|
G3BP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |