4.0
Summary
| Name |  G3BP1View Modifications |
| Full Name | Ras GTPase-activating protein-binding protein 1 |
| Synonyms | G3BP-1, ATP-dependent DNA helicase VIII, hDH VIII, GAP SH3 domain-binding protein 1 | G3BP |
| Primary ID | Q13283 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Pathways | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES |
| Function | ATP- and magnesium-dependent helicase that plays an essential role in innate immunity (PubMed:30510222). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA (PubMed:30804210). In addition, plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates activity 
phosphorylation
|
G3BP1 | 0.239 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES | |||
| + | G3BP1 | up-regulates 
|
Stress_granules | 0.7 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||
| + | N | down-regulates activity
binding
|
G3BP1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES | |||
| + | G3BP2 | up-regulates activity 
binding
|
G3BP1 | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||
| + | G3BP1 | down-regulates activity
binding
|
DDX58 | 0.339 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||
| + | G3BP1 | up-regulates quantity
|
DDX58 | 0.339 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||
| + | CAPRIN1 | up-regulates activity
binding
|
G3BP1 | 0.589 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | G3BP1 | up-regulates activity
binding
|
EIF2AK2 | 0.307 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||
| + | Viral_dsRNA | up-regulates activity
binding
|
G3BP1 | 0.7 |
| Publications: | 1 | |||
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||
| + | PARP10 | up-regulates activity
post translational modification
|
G3BP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | G3BP1 | up-regulates activity
binding
|
G3BP2 | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES | |||