3.0
Summary
| Name |  KHDC3LView Modifications |
| Full Name | KH domain-containing protein 3 |
| Synonyms | ES cell-associated transcript 1 protein | C6orf221, ECAT1 |
| Primary ID | Q587J8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | As part of the OOEP-KHDC3L scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Involved in the repair of DNA double strand breaks independent of its role in restarting stalled replication forks (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for maintenance of euploidy during cleavage-stage embryogenesis (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). Capable of binding RNA (By similarity). |
phosphorylation