Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273584 |
Ser820 |
YSTFLTSsPIRSRSP |
Homo sapiens |
|
pmid |
sentence |
19386263 |
Phosphorylation of hCenexin1 at S796 is critical for the hCenexin1-Plk1 interaction.Here we show that a splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2-dependent phospho-S796 motif within the extension. This interaction and Plk1 activity were important for proper recruitment of pericentrin and gamma-tubulin, and, ultimately, for formation of normal bipolar spindles. |
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