| + |
PRKCE | up-regulates activity 
phosphorylation
|
MIIP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273828 |
Ser303 |
YHIHRRKsFDASDTL |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 29038521 |
Here, we show that EGF stimulation induces PKCε-dependent phosphorylation of migration and invasion inhibitory protein (MIIP) at Ser303; this phosphorylation promotes the interaction between MIIP and RelA in the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activity of RelA and facilitates tumor metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIIP | up-regulates activity
binding
|
RELA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273829 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 29038521 |
Here, we show that EGF stimulation induces PKCε-dependent phosphorylation of migration and invasion inhibitory protein (MIIP) at Ser303; this phosphorylation promotes the interaction between MIIP and RelA in the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activity of RelA and facilitates tumor metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MIIP
- 
- 