Relation Results

Summary

Name MIIP
Full Name Migration and invasion-inhibitory protein
Synonyms IGFBP2-binding protein, Invasion-inhibitory protein 45, IIp45 | IIP45
Primary ID Q5JXC2
Links - -
Type protein
Relations 2
Function Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 ...
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Type: Score: Layout: SPV 
0.20.2PRKCEMIIPRELA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCEup-regulates activity img/direct-activation.png phosphorylation MIIP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273828 Ser303 YHIHRRKsFDASDTL Homo sapiens HCT-116 Cell
pmid sentence
Here, we show that EGF stimulation induces PKCε-dependent phosphorylation of migration and invasion inhibitory protein (MIIP) at Ser303; this phosphorylation promotes the interaction between MIIP and RelA in the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activity of RelA and facilitates tumor metastasis. 
Publications: 1 Organism: Homo Sapiens
+ MIIPup-regulates activity img/direct-activation.png binding RELA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273829 Homo sapiens HCT-116 Cell
pmid sentence
Here, we show that EGF stimulation induces PKCε-dependent phosphorylation of migration and invasion inhibitory protein (MIIP) at Ser303; this phosphorylation promotes the interaction between MIIP and RelA in the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activity of RelA and facilitates tumor metastasis. 
Publications: 1 Organism: Homo Sapiens
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