| + |
TTBK1 | down-regulates 
phosphorylation
|
MAPT |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148966 |
Ser515 |
SGDRSGYsSPGSPGT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16923168 |
Direct tau phosphorylation by ttbk1 at ser198, ser199, ser202 and ser422, which are also phosphorylated in phfs. Ttbk1 also induces tau aggregation in human neuronal cells in a dose-dependent manner. We conclude that ttbk1 is a neuron-specific dual kinase involved in tau phosphorylation at ad-related sites and is also associated with tau aggregation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148970 |
Ser516 |
GDRSGYSsPGSPGTP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16923168 |
Direct tau phosphorylation by ttbk1 at ser198, ser199, ser202 and ser422, which are also phosphorylated in phfs. Ttbk1 also induces tau aggregation in human neuronal cells in a dose-dependent manner. We conclude that ttbk1 is a neuron-specific dual kinase involved in tau phosphorylation at ad-related sites and is also associated with tau aggregation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148974 |
Ser519 |
SGYSSPGsPGTPGSR |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16923168 |
Direct tau phosphorylation by ttbk1 at ser198, ser199, ser202 and ser422, which are also phosphorylated in phfs. Ttbk1 also induces tau aggregation in human neuronal cells in a dose-dependent manner. We conclude that ttbk1 is a neuron-specific dual kinase involved in tau phosphorylation at ad-related sites and is also associated with tau aggregation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148978 |
Ser739 |
GSIDMVDsPQLATLA |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16923168 |
Direct tau phosphorylation by ttbk1 at ser198, ser199, ser202 and ser422, which are also phosphorylated in phfs. Ttbk1 also induces tau aggregation in human neuronal cells in a dose-dependent manner. We conclude that ttbk1 is a neuron-specific dual kinase involved in tau phosphorylation at ad-related sites and is also associated with tau aggregation. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
TTBK1 | up-regulates activity 
phosphorylation
|
DPYSL2 |
0.243 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279313 |
Thr514 |
SVTPKTVtPASSAKT |
Homo sapiens |
|
| pmid |
sentence |
| 32019603 |
TTBK1 induces complex formation of pCRMP2 with pTau.|These data suggest that TTBK1-induced T514 CRMP2 phosphorylation is dependent on both S522 phosphorylation by Cdk5 and T555 phosphorylation by RhoK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TTBK1
- 
- 