3.0
Summary
| Name |  RNF20View Modifications |
| Full Name | E3 ubiquitin-protein ligase BRE1A |
| Synonyms | BRE1-A, hBRE1, RING finger protein 20 | BRE1A |
| Primary ID | Q5VTR2 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
RNF20 | 0.537 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
RNF20 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM | up-regulates
phosphorylation
|
RNF20 | 0.537 |
| Publications: | 1 | Organism: | Homo Sapiens | |