| + |
ZNF318 | down-regulates activity 
binding
|
AR |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261187 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16469430 |
Using different promoters and cells, we confirmed that AR-mediated transactivation was repressed by TZF in a dose-dependent manner (Fig. 1A and B). Endogenous ARmediated transactivation was also inhibited by expression of TZF; These results indicate that amino acid residues 512–663 are essential for the repressive effect of TZF on AR-mediated transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC2 | up-regulates activity 
binding
|
ZNF318 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261188 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 16469430 |
A central domain of TZF is required for repression of AR-mediated transactivation. The results revealed that HDAC2 was coimmunoprecipitated with TZF (Fig. 6A), These results indicate that AR, TZF and HDAC2 form a ternary complex during the repression of AR-mediated transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZNF318
- 
- 