Summary

Name HDAC2
Full Name Histone deacetylase 2
Synonyms HD2
Primary ID Q92769
Links - -
Type protein
Relations 49
Inhibitors romidepsin; JWOGUUIOCYMBPV-GMFLJSBRSA-N; vorinostat; valproic acid; tacedinaline; N-[4-[(hydroxyamino)-oxomethyl]phenyl]carbamic acid [6-(diethylaminomethyl)-2-naphthalenyl]methyl ester; trichostatin A; panobinostat; 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide; belinostat; entinostat; N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide; CUDC-101; N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide; 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide; (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HDAC2 0.604
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC2 0.399
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC2 0.604
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation HDAC2 0.29
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 3 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png binding HDAC2 0.484
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ form complex img/form-complex.png binding BHC complex 0.687
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI2 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/direct_inhibition.png deacetylation CIITA 0.425
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ form complex img/form-complex.png binding MBD3/NuRD complex 0.785
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding ZNF318 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CCND1 0.484
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HPGD 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TWIST1 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation YY1 0.757
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png Epigenetic_regulation 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CoREST-HDAC complex 0.689
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MBD2/NuRD complex 0.788
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MECP2/SIN3A/HDAC complex 0.707
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png s-nitrosylation HDAC2 0.27
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC2 0.8
Publications: 1 Organism: Homo Sapiens