Relation Results

Summary

Name FBXW10
Full Name F-box/WD repeat-containing protein 10
Synonyms F-box and WD-40 domain-containing protein 10, Ubiquitin ligase-specificity factor |
Primary ID Q5XX13
Links - -
Type protein
Relations 3
Function Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and sub ...
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Type: Score: Layout: SPV 
0.20.620.2FBXW10CBX5Cullin 1-RBX1-Skp1GAPDH

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Relations
Regulator
Mechanism
target
score ℹ
+ FBXW10down-regulates quantity by destabilization img/direct_inhibition.png binding CBX5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271933 Homo sapiens HEK-293 Cell
pmid sentence
As expected, the SKP1 and CUL1 proteins, subunits of all F-box-containing E3 ligases, were also present in the immune complexes containing FBXO10 and BCL2. To test for FBXO10-induced ubiquitination of BCL2, 293T cells were transduced with retroviral vectors expressing Flag-tagged FBXO10, MYC-tagged BCL2, and HA-tagged ubiquitin, and cells were treated with the proteasome inhibitor PS-341 to enhance the detection of ubiquitinated proteins.Together, these data suggest that FBXO10 is a component of a ubiquitin ligase that can target BCL2 protein for degradation.
Publications: 1 Organism: Homo Sapiens
+ FBXW10up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.62
Identifier Residue Sequence Organism Cell Line
SIGNOR-271935 Homo sapiens HEK-293 Cell
pmid sentence
As expected, the SKP1 and CUL1 proteins, subunits of all F-box-containing E3 ligases, were also present in the immune complexes containing FBXO10 and BCL2. To test for FBXO10-induced ubiquitination of BCL2, 293T cells were transduced with retroviral vectors expressing Flag-tagged FBXO10, MYC-tagged BCL2, and HA-tagged ubiquitin, and cells were treated with the proteasome inhibitor PS-341 to enhance the detection of ubiquitinated proteins.Together, these data suggest that FBXO10 is a component of a ubiquitin ligase that can target BCL2 protein for degradation.
Publications: 1 Organism: Homo Sapiens
+ FBXW10up-regulates activity img/direct-activation.png polyubiquitination GAPDH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277841 Homo sapiens Hepatoma Cell Line
pmid sentence
Mechanistically, FBXW10 promotes GAPDH polyubiquitination and activation; VRK2-dependent phosphorylation of GAPDH Ser151 residue is critical for GAPDH ubiquitination and activation. 
Publications: 1 Organism: Homo Sapiens
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