+ |
AURKB | down-regulates activity
phosphorylation
|
CDCA2 |
0.459 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-274002 |
Ser542 |
KKINRRKsQETKCTK |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-274004 |
Ser977 |
EPGKRRKsFCISTLA |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-274001 |
Ser981 |
RRKSFCIsTLANTKA |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
Publications: |
3 |
Organism: |
Homo Sapiens |
+ |
CDCA2 | up-regulates activity
binding
|
PPP1CC |
0.38 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-274003 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |