| + |
AURKB | down-regulates activity 
phosphorylation
|
CDCA2 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274002 |
Ser542 |
KKINRRKsQETKCTK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280191 |
Ser893 |
SETKVRRsTRLQKDL |
Homo sapiens |
|
| pmid |
sentence |
| 23746640 |
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man.|Here, we show that Aurora B phosphorylates Repo-Man at S893, preventing its recruitment by histones. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274004 |
Ser977 |
EPGKRRKsFCISTLA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274001 |
Ser981 |
RRKSFCIsTLANTKA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CDCA2 | up-regulates activity 
binding
|
PPP1CC |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274003 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32938714 |
This result demonstrates that the three sites of Repo-Man (Ser-543, Ser-977, and Ser-981) are phosphorylated by Aurora B in early mitosis. We uncover that PP1γ is recruited to mitotic chromosomes by its regulatory subunit Repo-Man in the absence of Aurora B activity and that Aurora B regulates dissociation of PP1γ by phosphorylating and disrupting PP1γ-Repo-Man interactions on chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CDCA2
- 
- 