Summary

Name CDCA2
Full Name Cell division cycle-associated protein 2
Synonyms Recruits PP1 onto mitotic chromatin at anaphase protein, Repo-Man |
Primary ID Q69YH5
Links - -
Type protein
Relations 4
Function Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CDCA2 0.465
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP1CC 0.382
Publications: 1 Organism: Homo Sapiens