| + |
UBE2I | down-regulates 
sumoylation
|
PLAG1 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126044 |
Lys244 |
NQELLKVkTEPVDFL |
Homo sapiens |
|
| pmid |
sentence |
| 15208321 |
Sumoylation decreases the transcriptional activity of plag1 / plag1 is sumoylated at 2 specific lysine residues (lys-244 and lys-263) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126048 |
Lys263 |
CNVSVPIkDELLPVM |
Homo sapiens |
|
| pmid |
sentence |
| 15208321 |
Sumoylation decreases the transcriptional activity of plag1 / plag1 is sumoylated at 2 specific lysine residues (lys-244 and lys-263) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLAG1 | up-regulates quantity by expression 
transcriptional regulation
|
ABCC6 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254925 |
|
|
Homo sapiens |
HEK-293 Cell, Hep-G2 Cell |
| pmid |
sentence |
| 18850323 |
We identified ABCC6 as a target gene for transcriptional induction by PLAG1 and PLAGL1, transcription factors from the PLAG family of cell cycle progression-related DNA-binding proteins. Both these factors are shown to bind to the same single consensus-binding element in the ABCC6 proximal promoter in cell lines of hepatic and renal origin by reporter gene assay, electrophoretic mobility shift assay and chromatin immunoprecipitation. PLAG-mediated ABCC6 transactivation may play an important role in determining the level of tissue-specific expression of this gene. The described mechanism can also find potential application in therapeutic interventions in forms of PXE related to impaired ABCC6 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAG1 | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11888928 |
Plagl1 has been shown to prevent the proliferation of tumor cells by inducing cell cycle arrest and apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EP300 | up-regulates 
acetylation
|
PLAG1 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16207715 |
Plag1 and plagl2 are also regulated by acetylation. They are acetylated and activated by p300 and deacetylated and repressed by hdac7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAG1 | up-regulates quantity by expression
transcriptional regulation
|
IGF2 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120363 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14695992 |
Plag1 has been shown be a transcriptional activator of igf2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
PLAG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC7 | down-regulates
deacetylation
|
PLAG1 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16207715 |
Plag1 and plagl2 are also regulated by acetylation. They are acetylated and activated by p300 and deacetylated and repressed by hdac7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAG1 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11888928 |
Plagl1 has been shown to prevent the proliferation of tumor cells by inducing cell cycle arrest and apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PLAG1
- 
- 