| + |
PLAGL1 | up-regulates quantity by expression 
transcriptional regulation
|
ABCC6 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254926 |
|
|
Homo sapiens |
HEK-293 Cell, Hep-G2 Cell |
| pmid |
sentence |
| 18850323 |
We identified ABCC6 as a target gene for transcriptional induction by PLAG1 and PLAGL1, transcription factors from the PLAG family of cell cycle progression-related DNA-binding proteins. Both these factors are shown to bind to the same single consensus-binding element in the ABCC6 proximal promoter in cell lines of hepatic and renal origin by reporter gene assay, electrophoretic mobility shift assay and chromatin immunoprecipitation. PLAG-mediated ABCC6 transactivation may play an important role in determining the level of tissue-specific expression of this gene. The described mechanism can also find potential application in therapeutic interventions in forms of PXE related to impaired ABCC6 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
ABCC6 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255182 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
ID4-mediated SOX2 induction enhanced ABCC3 and ABCC6 expression through direct transcriptional regulation, indicating that ID4 regulates the chemoresistance of iGSCs by promoting SOX2-mediated induction of ABC transporters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAG1 | up-regulates quantity by expression
transcriptional regulation
|
ABCC6 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254925 |
|
|
Homo sapiens |
HEK-293 Cell, Hep-G2 Cell |
| pmid |
sentence |
| 18850323 |
We identified ABCC6 as a target gene for transcriptional induction by PLAG1 and PLAGL1, transcription factors from the PLAG family of cell cycle progression-related DNA-binding proteins. Both these factors are shown to bind to the same single consensus-binding element in the ABCC6 proximal promoter in cell lines of hepatic and renal origin by reporter gene assay, electrophoretic mobility shift assay and chromatin immunoprecipitation. PLAG-mediated ABCC6 transactivation may play an important role in determining the level of tissue-specific expression of this gene. The described mechanism can also find potential application in therapeutic interventions in forms of PXE related to impaired ABCC6 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ABCC6
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