| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25490267 |
Together, our results provide compelling evidence that MAP4K4 promotes FA dynamics by regulating IQSEC1 and Arf6 pathway and controlling endocytosis of integrin.|Upon targeting to FAs via MTs, MAP4K4 can bind and phosphorylate IQSEC1, which in turn activates Arf6 and endocytosis, leading to turnover of FAs. |
|