3.0
Summary
| Name |  SLC27A4
|
| Full Name | Long-chain fatty acid transport protein 4 |
| Synonyms | FATP-4, Fatty acid transport protein 4, Arachidonate--CoA ligase, 6.2.1.15, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 4, Very long-chain acyl-CoA synthetase 4, ACSVL4, 6.2.1.- | ACSVL4, FATP4 |
| Primary ID | Q6P1M0 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane (PubMed:12556534, PubMed:21395585). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (PubMed:24269233). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SLC27A4 | up-regulates quantity 
relocalization
|
Fatty acid | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |