| + |
ULK3 | up-regulates activity 
phosphorylation
|
ULK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260793 |
Ser300 |
KKDQEGDsAAALSLY |
Homo sapiens |
|
| pmid |
sentence |
| 20643644 |
We show that ULK3 autophosphorylation occurs at four serine residues (Ser-300, Ser-350, Ser-384, and Ser-464) situated outside of the KD | Thus, autophosphorylation of ULK3 may involve conformational changes resulted in exposure of CTD to KD and consequently in generation of the catalytically active kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260794 |
Ser350 |
ELKAIVSsSNQALLR |
Homo sapiens |
|
| pmid |
sentence |
| 20643644 |
We show that ULK3 autophosphorylation occurs at four serine residues (Ser-300, Ser-350, Ser-384, and Ser-464) situated outside of the KD | Thus, autophosphorylation of ULK3 may involve conformational changes resulted in exposure of CTD to KD and consequently in generation of the catalytically active kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260795 |
Ser384 |
RLLAALEvASAAMAK |
Homo sapiens |
|
| pmid |
sentence |
| 20643644 |
We show that ULK3 autophosphorylation occurs at four serine residues (Ser-300, Ser-350, Ser-384, and Ser-464) situated outside of the KD | Thus, autophosphorylation of ULK3 may involve conformational changes resulted in exposure of CTD to KD and consequently in generation of the catalytically active kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260796 |
Ser464 |
DKEGLSEsVRSSCTL |
Homo sapiens |
|
| pmid |
sentence |
| 20643644 |
We show that ULK3 autophosphorylation occurs at four serine residues (Ser-300, Ser-350, Ser-384, and Ser-464) situated outside of the KD | Thus, autophosphorylation of ULK3 may involve conformational changes resulted in exposure of CTD to KD and consequently in generation of the catalytically active kinase. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
ULK3 | up-regulates activity
phosphorylation
|
GLI1 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260797 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19878745 |
We show that ULK3 is able to phosphorylate three mammalian GLI proteins in vitro. | Our data suggest that serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ULK3 | up-regulates activity
phosphorylation
|
GLI3 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260799 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19878745 |
We show that ULK3 is able to phosphorylate three mammalian GLI proteins in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ULK3 | down-regulates activity 
phosphorylation
|
IST1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26011858 |
ULK3 phosphorylation of IST1 is required to sustain the abscission checkpoint and inhibits IST1 function in abscission. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ULK3 | up-regulates activity
phosphorylation
|
GLI2 |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260798 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19878745 |
We show that ULK3 is able to phosphorylate three mammalian GLI proteins in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ULK3
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