| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
GLI2 |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148472 |
Ser820 |
VSSAYTVsRRSSGIS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16611981 |
The degradation of Gli2 requires the phosphorylation of a cluster of numerous serine residues in its carboxyl terminus by protein kinase A and subsequently by casein kinase 1 and glycogen synthase kinase 3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249589 |
Ser832 |
GISPYFSsRRSSEAS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16611981 |
The degradation of Gli2 requires the phosphorylation of a cluster of numerous serine residues in its carboxyl terminus by protein kinase A and subsequently by casein kinase 1 and glycogen synthase kinase 3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249590 |
Ser863 |
DPISTDAsRRSSEAS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16611981 |
The degradation of Gli2 requires the phosphorylation of a cluster of numerous serine residues in its carboxyl terminus by protein kinase A and subsequently by casein kinase 1 and glycogen synthase kinase 3. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GLI2 | up-regulates quantity by expression 
transcriptional regulation
|
HHIP |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209635 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
SPOP | down-regulates quantity
ubiquitination
|
GLI2 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268860 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20463034 |
RNAi knockdown of Spop (a substrate-binding adaptor for the cullin3-based ubiquitin E3 ligase) in Sufu mutant mouse embryonic fibroblasts (MEFs) can restore the levels of Gli2 and Gli3 full-length proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRG | up-regulates quantity
transcriptional regulation
|
GLI2 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269267 |
|
|
|
|
| pmid |
sentence |
| 31390799 |
Despite RXRγ being heavily down-regulated upon silencing (average silencing was about 80%), the reduction in Gli2 expression levels was statistically significant only for Clobetasol-treated but not for Gefitinib-treated cells. |
|
| Publications: |
1 |
| + |
GLI2 | up-regulates quantity
transcriptional regulation
|
OLIG2 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK6142 |
Therefore, Gli2 activity regulates the late phase of Olig2 gene expression in the ventral neuroepithelium and its subsequent production of OPC cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF7 | up-regulates quantity by stabilization 
binding
|
GLI2 |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19549984 |
Kif7 physically interacted with Gli transcription factors and controlled their proteolysis and stability, and acted both positively and negatively in Hh signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
ULK3 | up-regulates activity
phosphorylation
|
GLI2 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260798 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19878745 |
We show that ULK3 is able to phosphorylate three mammalian GLI proteins in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI2 | up-regulates
|
Myelination |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269214 |
|
|
|
|
| pmid |
sentence |
| NBK6142 |
|
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269215 |
|
|
|
|
| pmid |
sentence |
| NBK6142 |
|
|
| Publications: |
2 |
| + |
PRKACA | down-regulates
phosphorylation
|
GLI2 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
In the absence of hh ligands, cubitus interruptus (in drosophila) and gli2 and gli3 (in vertebrates) are phosphorylated by protein kinase a and glycogen synthase kinase-3beta and are proteolytically processed in vertebrates, pka-mediated phosphorylation of gli2 and gli3 initiates a phosphorylation cascade that leads to processing into repressors of transcription or frank degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154273 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
In the absence of hh ligands, cubitus interruptus (in drosophila) and gli2 and gli3 (in vertebrates) are phosphorylated by protein kinase a and glycogen synthase kinase-3beta and are proteolytically processed in vertebrates, pka-mediated phosphorylation of gli2 and gli3 initiates a phosphorylation cascade that leads to processing into repressors of transcription or frank degradation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
PTCH1 |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209632 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
SHH | up-regulates activity
|
GLI2 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148349 |
|
|
Homo sapiens |
Osteoblast |
| pmid |
sentence |
| 16880529 |
Finally, Sonic hedgehog (Shh) stimulates BMP-2 promoter activity and osteoblast differentiation, and the effects of Shh are mediated by Gli2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
SUFU | up-regulates quantity by stabilization
binding
|
GLI2 |
0.907 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268867 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20463034 |
We show that loss of suppressor of fused (Sufu; an inhibitory effector for Gli proteins) results in destabilization of Gli2 and Gli3 full-length activators but not of their C-terminally processed repressors, whereas overexpression of Sufu stabilizes them. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
CXCL1 | up-regulates quantity by expression
transcriptional regulation
|
GLI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
The data suggest that smo is in fact the source of two signals relevant to the activation of gli: one involving g(i) and the other involving events at smo's c-tail independent of g(i). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1L | up-regulates
phosphorylation
|
GLI2 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179972 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18698484 |
Gli2 is phosphorylated by gsk3 and ck1 for the fbxw11 (betatrcp2)-mediated degradation ci is phosphorylated by pka at multiple sites priming phosphorylation by both gsk3 and cki, leading to partial proteolysis. The pka, gsk3, and cki sites are conserved in gli2 and gli3, vertebrate homologs of ci that are similarly processed |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16481469 |
Gli2 is phosphorylated by gsk3 and ck1 for the fbxw11 (betatrcp2)-mediated degradation ci is phosphorylated by pka at multiple sites priming phosphorylation by both gsk3 and cki, leading to partial proteolysis. The pka, gsk3, and cki sites are conserved in gli2 and gli3, vertebrate homologs of ci that are similarly processed |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SUFU | down-regulates activity
relocalization
|
GLI2 |
0.907 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129065 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16316410 |
We demonstrate here that Su(fu) prevents the nuclear accumulation of Gli1 and Gli2 through multiple mechanisms |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
4-(2,4,5-tripyridin-4-yl-3-thiophenyl)pyridine | down-regulates
chemical inhibition
|
GLI2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188866 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
Both molecules gant58 and gant61 were capable of interfering with gli1 as well as gli2-mediated transcription in a dose-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
FOXF1 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254216 |
|
|
Homo sapiens |
Lung Microvascular Endothelial Cell |
| pmid |
sentence |
| 23034409 |
we propose that chromatin looping between SDR and FOXF1 allows GLI2 to increase FOXF1 activity specifically in lung endothelium. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline | down-regulates
chemical inhibition
|
GLI2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154756 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell |
| pmid |
sentence |
| 17494766 |
Gant61 was able to efficiently block gli1 as well as gli2-induced transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI2 | down-regulates 
|
PPARG |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256224 |
|
|
|
|
| pmid |
sentence |
| 29205155 |
Molecularly, Gli2 is the principle transcription factor in the Gli family to mediate the anti-adipogenic and anti-lipogenic effects of Hh signaling |
|
| Publications: |
1 |
| Tissue: |
Mammary Epithelial Cell |
| + |
CSNK1A1 | down-regulates
phosphorylation
|
GLI2 |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16611981 |
Gli2 can also be phosphorylated directly by ck-1 at the non-optimal sites |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
In the absence of hedgehog signaling, gli1 is transcriptionally repressed, gli2 is phosphorylated by gsk3 and ck1 for the fbxw11 (betatrcp2)-mediated degradation, and gli3 is processed to a cleaved repressor. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
GLI1 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209629 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
GLI2 | form complex 
binding
|
GLI1/GLI2 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269210 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 32766732 |
GLI1 and GLI2 were shown to co-immunoprecipitate in PANC1 pancreatic cancer cells and RMS13 rhabdomyosarcoma cells.|Chromatin immunoprecipitation showed that GLI1 and GLI2 occupied the same regions at the BCL2, MYCN and CCND1 promoters. Furthermore, depletion of GLI1 inhibited GLI2 occupancy at these promoters, suggesting that GLI1/GLI2 interaction is required for the recruitment of GLI2 to these sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
IFITM5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254217 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23530031 |
Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. Bril transcription is activated by Sp1, Sp3, OSX, and GLI2 and by CpG demethylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI2 | up-regulates
|
Cell_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269223 |
|
|
|
|
| pmid |
sentence |
| 33125874 |
Inhibition of Gli1 with simultaneous increase in Gli2 promotes migration of vNSC-derived cells to demyelinated lesions |
|
| Publications: |
1 |
| + |
SOX17 | up-regulates
|
GLI2 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269218 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 33083751 |
Sox17 ablation lowered endogenous Gli2 and Olig2+ cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
BMP2 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148346 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16880529 |
The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates quantity by destabilization
phosphorylation
|
GLI2 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19056373 |
These results indicate that phosphorylation of Gli2 by PKA induces Gli2 processing and destabilization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
BTRC | down-regulates quantity by destabilization
ubiquitination
|
GLI2 |
0.636 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146109 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16611981 |
The phosphorylated gli2 protein interacts with beta-trcp, and is ubiquitinated and degraded by the proteasome |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
3.0
GLI2
- 
- 