Summary

Name IYD
Full Name Iodotyrosine deiodinase 1
Synonyms IYD-1, Iodotyrosine dehalogenase 1 | C6orf71, DEHAL1
Primary ID Q6PHW0
Links - -
Type protein
Relations 4
Pathways Thyroid Hormone Metabolism
Function Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:25395621, PubMed:18434651). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways (PubMed:18434651). Acts more efficiently on monoiodotyrosine than on diiodotyrosine (PubMed:15289438).

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification 3,5-diiodo-L-tyrosine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity img/direct-activation.png chemical modification L-tyrosine zwitterion 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity img/direct-activation.png chemical modification iodide 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ down-regulates quantity img/direct_inhibition.png chemical modification 3-iodo-L-tyrosine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism