Relation Results

Summary

Name LARP1
Full Name La-related protein 1
Synonyms La ribonucleoprotein domain family member 1 | KIAA0731, LARP
Primary ID Q6PKG0
Links - -
Type protein
Relations 3
Function RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and ...
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Type: Score: Layout: SPV 
0.2890.304AKT1LARP1mTORC1

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ down-regulates activity img/direct_inhibition.png phosphorylation LARP1 0.289
Identifier Residue Sequence Organism Cell Line
SIGNOR-260992 Ser1056 EGRKRCPsQSSSRPA Homo sapiens HEK-293T Cell
pmid sentence
LARP1 is a direct substrate of Akt/S6K1 and mTORC1. Akt is a physiologically relevant primary kinase for S770/S979 phosphorylation of LARP1|Importantly, phosphorylation of LARP1 by mTORC1 and Akt/S6K1 dissociates it from 5’UTRs and relieves its inhibitory activity on RP mRNA translation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-260991 Ser847 EHRPRTAsISSSPSE Homo sapiens HEK-293T Cell
pmid sentence
LARP1 is a direct substrate of Akt/S6K1 and mTORC1. Akt is a physiologically relevant primary kinase for S770/S979 phosphorylation of LARP1|Importantly, phosphorylation of LARP1 by mTORC1 and Akt/S6K1 dissociates it from 5’UTRs and relieves its inhibitory activity on RP mRNA translation.
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding mTORC1 0.304
Identifier Residue Sequence Organism Cell Line
SIGNOR-260993 Homo sapiens HEK-293T Cell
pmid sentence
LARP1-mTORC1 interaction occurs through direct protein-protein contacts. phosphorylated LARP1 facilitates mTORC1-dependent phosphorylation of S6K1 and 4EBP1 on the LARP1-containing mRNPs by scaffolding mTORC1.
Publications: 1 Organism: Homo Sapiens
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