3.0
Summary
| Name |  BLOC1S2
|
| Full Name | Biogenesis of lysosome-related organelles complex 1 subunit 2 |
| Synonyms | BLOC-1 subunit 2, Centrosome-associated protein | BLOS2, CEAP |
| Primary ID | Q6QNY1 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421). |
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