Summary

Name FIP1L1
Full Name Pre-mRNA 3'-end-processing factor FIP1
Synonyms hFip1, FIP1-like 1 protein, Factor interacting with PAP, Rearranged in hypereosinophilia | FIP1, RHE
Primary ID Q6UN15
Links - -
Type protein
Relations 2
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PAPOLA 0.782
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CPSF complex 0.897
Publications: 1 Organism: Homo Sapiens