| + |
ERK1/2 | up-regulates activity 
phosphorylation
|
PAPOLA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268341 |
Ser537 |
DNSMSVPsPTSATKT |
Mus musculus |
Oocyte |
| pmid |
sentence |
| 34048556 |
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268342 |
Ser545 |
PTSATKTsPLNSSGS |
Mus musculus |
Oocyte |
| pmid |
sentence |
| 34048556 |
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268343 |
Ser558 |
GSSQGRNsPAPAVTA |
Mus musculus |
Oocyte |
| pmid |
sentence |
| 34048556 |
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
CDK1 | up-regulates activity
phosphorylation
|
PAPOLA |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268338 |
Ser537 |
DNSMSVPsPTSATKT |
Mus musculus |
Oocyte |
| pmid |
sentence |
| 34048556 |
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268339 |
Ser545 |
PTSATKTsPLNSSGS |
Mus musculus |
Oocyte |
| pmid |
sentence |
| 34048556 |
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268340 |
Ser558 |
GSSQGRNsPAPAVTA |
Mus musculus |
Oocyte |
| pmid |
sentence |
| 34048556 |
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
FIP1L1 | up-regulates
binding
|
PAPOLA |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14749727 |
Recombinant hfip1 is sufficient to stimulate the in vitro polyadenylation activity of pap in a u-rich element-dependent manner. hfip1, cpsf160 and pap form a ternary complex in vitro, suggesting that hfip1 and cpsf160 act together in poly(a) site recognition and in cooperative recruitment of pap to the rna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AHCYL2 | down-regulates activity 
binding
|
PAPOLA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268330 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19224921 |
Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation|In addition to CPSF, IRBIT interacted in vitro with poly(A) polymerase (PAP), which is the enzyme recruited by CPSF to elongate the poly(A) tail, and inhibited PAP activity in a phosphorylation-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AHCYL1 | down-regulates activity
binding
|
PAPOLA |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268329 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19224921 |
Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation|In addition to CPSF, IRBIT interacted in vitro with poly(A) polymerase (PAP), which is the enzyme recruited by CPSF to elongate the poly(A) tail, and inhibited PAP activity in a phosphorylation-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CPSF complex | up-regulates activity
relocalization
|
PAPOLA |
0.787 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14749727 |
Recombinant hfip1 is sufficient to stimulate the in vitro polyadenylation activity of pap in a u-rich element-dependent manner. hfip1, cpsf160 and pap form a ternary complex in vitro, suggesting that hfip1 and cpsf160 act together in poly(a) site recognition and in cooperative recruitment of pap to the rna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
PAPOLA | up-regulates quantity by stabilization
chemical modification
|
messenger RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268327 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19224921 |
Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation|In addition to CPSF, IRBIT interacted in vitro with poly(A) polymerase (PAP), which is the enzyme recruited by CPSF to elongate the poly(A) tail, and inhibited PAP activity in a phosphorylation-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
PAPOLA | up-regulates 
|
mRNA_polyadenylation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268325 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19224921 |
Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation|In addition to CPSF, IRBIT interacted in vitro with poly(A) polymerase (PAP), which is the enzyme recruited by CPSF to elongate the poly(A) tail, and inhibited PAP activity in a phosphorylation-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
3.0
PAPOLA
- 
- 