Summary

Name RSPO2
Full Name R-spondin-2
Synonyms Roof plate-specific spondin-2, hRspo2
Primary ID Q6UXX9
Links - -
Type protein
Relations 4
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding LGR4 0.757
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LGR5 0.681
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SDC4 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination FZD4 0.322
Publications: 1 Organism: Homo Sapiens