| + |
PRKCD | up-regulates activity 
phosphorylation
|
SDC4 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116265 |
Ser179 |
MKKKDEGsYDLGKKP |
Rattus norvegicus |
|
| pmid |
sentence |
| 11916978 |
The phosphorylation state of Ser(183) in the cytoplasmic tail of syndecan-4 determines the binding affinity of the cytoplasmic tail to phosphatidylinositol 4,5-bisphosphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase C (PKC) alpha. We sought to identify the kinase responsible for this phosphorylation and to determine its downstream effects on PKCalpha activity and on endothelial cell function. Among several PKC isoenzymes tested, only PKCalpha and -delta were able to specifically phosphorylate Ser(183) in vitro. However, studies in cultured endothelial cells showed that the phosphorylation level of syndecan-4 was significantly reduced in endothelial cells expressing a dominant negative (DN) PKCdelta but not a DN PKCalpha mutant. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PRKCA | up-regulates activity
phosphorylation
|
SDC4 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249149 |
Ser179 |
MKKKDEGsYDLGKKP |
Rattus norvegicus |
Endothelial Cell |
| pmid |
sentence |
| 11916978 |
The phosphorylation state of Ser(183) in the cytoplasmic tail of syndecan-4 determines the binding affinity of the cytoplasmic tail to phosphatidylinositol 4,5-bisphosphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase C (PKC) alpha. We sought to identify the kinase responsible for this phosphorylation and to determine its downstream effects on PKCalpha activity and on endothelial cell function. Among several PKC isoenzymes tested, only PKCalpha and -delta were able to specifically phosphorylate Ser(183) in vitro. However, studies in cultured endothelial cells showed that the phosphorylation level of syndecan-4 was significantly reduced in endothelial cells expressing a dominant negative (DN) PKCdelta but not a DN PKCalpha mutant. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SDC4 | up-regulates
binding
|
DVL3 |
0.246 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co-receptors, syndecan 4 directly interacts with dvl during pcp 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
RAC1 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255849 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 23290138 |
Rac1 is associated with Sdc4 and is activated by FN binding […] We observed that over-expression of Fzd7, or stimulation with FN resulted in increased levels of active Rac1 in primary myoblasts |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
ADAM12 | up-regulates
binding
|
SDC4 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12509413 |
The adam12 cysteine-rich domain (radam12-cys) supports cell attachment using syndecan-4 as a primary cell surface receptor that subsequently triggers beta(1) integrin-dependent cell spreading, stress fiber assembly, and focal adhesion formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
SDC4 | form complex 
binding
|
FN1/SDC4 |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255286 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
We found that binding of ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells |
|
| Publications: |
1 |
| + |
SDC4 | up-regulates activity
binding
|
SDCBP |
0.876 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12241528 |
PDZ domain-containing scaffold proteins (syntenin and CASK) bind to the C-terminus of the syndecan-4 cytoplasmic domain and co-ordinate clustering of receptors and connection to the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates
binding
|
DVL2 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co receptors, syndecan 4 directly interacts with dvl during pcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
CASK |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282604 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12241528 |
PDZ domain-containing scaffold proteins (syntenin and CASK) bind to the C-terminus of the syndecan-4 cytoplasmic domain and co-ordinate clustering of receptors and connection to the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2R | up-regulates quantity by expression 
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254852 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Integrator complex | down-regulates quantity by repression 
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261480 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
trastuzumab | down-regulates activity 
binding
|
SDC4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33810568 |
Recently, we demonstrated that trastuzumab reduces syndecan-4 expression in anoikis-resistant endothelial cells and this interaction controls cellular events, such as proliferation, adhesion and angiogenesis, in these cells [138]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
EGFR |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282613 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26350464 |
We find that sites in the extracellular domains of Sdc1 and Sdc4 are responsible for capturing HER2 and EGFR, respectively, along with the α3β1 integrin. This ternary receptor complex docks with the α6β4 integrin via its cytoplasmic link with the syndecan, leading to β4 phosphorylation and downstream signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
FGFR1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282598 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23970415 |
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis. These effects are achieved through syndecan-4 functioning as both a co-receptor for the fibroblast growth factor receptors (FGFR1-FGFR4) and its ability to independently activate signaling pathways upon ligand binding. As an FGFR co-receptor, syndecan-4 strengthens the duration and intensity of downstream signaling upon ligand binding |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
FGFR2 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282599 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23970415 |
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis. These effects are achieved through syndecan-4 functioning as both a co-receptor for the fibroblast growth factor receptors (FGFR1-FGFR4) and its ability to independently activate signaling pathways upon ligand binding. As an FGFR co-receptor, syndecan-4 strengthens the duration and intensity of downstream signaling upon ligand binding |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
FGFR3 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282600 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23970415 |
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis. These effects are achieved through syndecan-4 functioning as both a co-receptor for the fibroblast growth factor receptors (FGFR1-FGFR4) and its ability to independently activate signaling pathways upon ligand binding. As an FGFR co-receptor, syndecan-4 strengthens the duration and intensity of downstream signaling upon ligand binding |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
FGFR4 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282601 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23970415 |
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis. These effects are achieved through syndecan-4 functioning as both a co-receptor for the fibroblast growth factor receptors (FGFR1-FGFR4) and its ability to independently activate signaling pathways upon ligand binding. As an FGFR co-receptor, syndecan-4 strengthens the duration and intensity of downstream signaling upon ligand binding |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RSPO3 | up-regulates
binding
|
SDC4 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21397842 |
Here, we show that rspo3 binds syndecan 4 (sdc4) and that together they activate wnt/pcp signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MALL | up-regulates quantity by stabilization
binding
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282612 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 42017444 |
Confocal microscopy validated the co-localization of MALL and SDC4, and reciprocal co-immunoprecipitation further demonstrated a robust cellular association between the two proteins (Figure 5B,C).Cycloheximide chase assays conducted with or without the proteasome inhibitor MG132 or the lysosome inhibitor bafilomycin A1 demonstrated that MALL selectively impedes lysosomal degradation and thereby stabilizes SDC4 protein levels (Figure 6C). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2RL1 | up-regulates quantity by expression
transcriptional regulation
|
SDC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254844 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FN1 | up-regulates activity
binding
|
SDC4 |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23290138 |
Sdc4 is a high affinity receptor for fibronectin (FN) […] Therefore, we conclude that Sdc4 binds FN on activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
A3/b1 integrin |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26350464 |
We find that sites in the extracellular domains of Sdc1 and Sdc4 are responsible for capturing HER2 and EGFR, respectively, along with the α3β1 integrin. This ternary receptor complex docks with the α6β4 integrin via its cytoplasmic link with the syndecan, leading to β4 phosphorylation and downstream signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
A6/b4 integrin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282617 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33810567 |
Apart from FGFR signaling, syndecan-4 also affects epidermal growth factor (EGF)- mediated signaling, albeit through a different mechanism: It has been shown that EGFdependent cancer cell migration is mediated through a complex of human epidermal growth factor receptor-1 (EGFR), α6β4 integrin and Sdc4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | form complex
binding
|
FZD7/SDC4 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255847 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 23290138 |
We next examined whether endogenous Fzd7 and Sdc4 form a receptor complex in satellite cells […] Therefore, we conclude that Fzd7 and Sdc4 form a co-receptor complex in activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SDC4 | up-regulates activity
binding
|
PRKCA |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282605 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12241528 |
Syndecan-4 also binds and activates protein kinase Calpha in the presence of phosphatidylinositol 4,5-bisphosphate, and regulates signalling by Rho-family GTPases and focal adhesion kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates activity
binding
|
PARD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33810568 |
Recent works identified PAR-3 as a syndecan-4-binding protein and the syndecan-4/PAR-3 signaling complex participates in Thy-1/CD90-induced focal adhesion disassembly in mesenchymal cells [132]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hypoxia | up-regulates
|
SDC4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282621 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26084985 |
Hypoxia is one of the factors regulating syndecan-4 expression in human colon cancer cells, as it can induce its expression, along with alpha 5 integrin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates
binding
|
DVL1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co-receptors, syndecan 4 directly interacts with dvl during pcp 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RSPO2 | up-regulates
binding
|
SDC4 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21397842 |
We show that rspo3 binds syndecan 4 (sdc4) and that together they activate wnt/pcp signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
SDC4 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SDC4
- 
- 