Summary

Name KSR2
Full Name Kinase suppressor of Ras 2
Synonyms hKSR2
Primary ID Q6VAB6
Links - -
Type protein
Relations 9
Function Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation KSR2 0.262
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation KSR2 0.262
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ARAF 0.529
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BRAF 0.595
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAF1 0.583
Publications: 1 Organism: Homo Sapiens