| + |
PPP3CC | up-regulates activity 
dephosphorylation
|
NFATC2 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248509 |
Ser168 |
YREPLCLsPASSGSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248510 |
Ser171 |
PLCLSPAsSGSSASF |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248511 |
Ser172 |
LCLSPASsGSSASFI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248512 |
Ser174 |
LSPASSGsSASFISD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248513 |
Ser175 |
SPASSGSsASFISDT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248514 |
Ser177 |
ASSGSSAsFISDTFS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248515 |
Ser180 |
GSSASFIsDTFSPYT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248516 |
Ser213 |
QNIPAHYsPRTSPIM |
Homo sapiens |
|
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248517 |
Ser217 |
AHYSPRTsPIMSPRT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248518 |
Ser221 |
PRTSPIMsPRTSLAE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248519 |
Ser268 |
VALPPGAsPQRSRSP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248520 |
Ser274 |
ASPQRSRsPSPQPSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248521 |
Ser276 |
PQRSRSPsPQPSSHV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248522 |
Ser280 |
RSPSPQPsSHVAPQD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248523 |
Ser326 |
PPKMWKTsPDPSPVS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Publications: |
15 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
PPP3CC | up-regulates activity
dephosphorylation
|
KSR2 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248525 |
Ser198 |
IRTHLSQsPRVPSKC |
Mus musculus |
|
| pmid |
sentence |
| 19560418 |
These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248527 |
Ser313 |
TALHRSKsHEFQLGH |
Mus musculus |
|
| pmid |
sentence |
| 19560418 |
These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248526 |
Thr290 |
NKLKPPGtPPPSSRK |
Mus musculus |
|
| pmid |
sentence |
| 19560418 |
These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
PPP3CC | down-regulates quantity by destabilization 
dephosphorylation
|
FLNA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248507 |
Ser2152 |
TRRRRAPsVANVGSH |
Homo sapiens |
|
| pmid |
sentence |
| 16442073 |
Filamin is a phosphoprotein that organizes actin filaments into networks. We report that a purified C-terminal recombinant region of filamin is a suitable substrate for calcineurin |Mutagenesis analysis showed that a dephosphorylation step occurred in Ser 2152, which was previously shown to provide resistance to calpain cleavage when endogenous PKA is activated. In contrast, phosphorylation of Ser 2152 was recently reported to be necessary for membrane dynamic changes. In this regard, we found that CsA protects filamin in platelets from calpain degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CC | up-regulates activity
dephosphorylation
|
DNM1L |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248506 |
Ser637 |
VPVARKLsAREQRDC |
Homo sapiens |
|
| pmid |
sentence |
| 18838687 |
When mitochondrial depolarization is associated with sustained cytosolic Ca(2+) rise, it activates the cytosolic phosphatase calcineurin that normally interacts with Drp1. Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CC |
dephosphorylation
|
PPP1R1A |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248524 |
Ser67 |
LKSTLAMsPRQRKKM |
Rattus norvegicus |
|
| pmid |
sentence |
| 11278334 |
In vitro and in vivo studies indicated that phospho-Ser-67 inhibitor-1 was dephosphorylated by protein phosphatases-2A and -2B. | However, inhibitor-1 phosphorylated at Ser-67 was a less efficient substrate for cAMP-dependent protein kinase. These results demonstrate regulation of a Cdk5-dependent phosphorylation site in inhibitor-1 and suggest a role for this site in modulating the amplitude of signal transduction events that involve cAMP-dependent protein kinase activation. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PPP3CC | up-regulates activity
dephosphorylation
|
BAD |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248528 |
Ser75 |
EIRSRHSsYPAGTED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10195903 |
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD|Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248529 |
Ser99 |
PFRGRSRsAPPNLWA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10195903 |
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD|Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPP3CC |
dephosphorylation
|
DNM2 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248508 |
Ser764 |
LQSASSHsPTPQRRP |
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PPP3CC | up-regulates
relocalization
|
NFATC1 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179796 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18676376 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Skeletal Muscle |
| + |
IGF1 | up-regulates 
|
PPP3CC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235828 |
|
|
Mus musculus |
C2C12 Cell, Satellite Cell |
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| Pathways: | IGF and Myogenesis |
| + |
CALM1 | up-regulates
binding
|
PPP3CC |
0.657 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALM3 | up-regulates
binding
|
PPP3CC |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266340 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CC | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251735 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CALM2 | up-regulates
binding
|
PPP3CC |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CC | up-regulates
|
MEF2C |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
AKAP5 | up-regulates activity
relocalization
|
PPP3CC |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261291 |
|
|
Rattus norvegicus |
E-18 Rat Primary Hippocampal Neuron |
| pmid |
sentence |
| 20694001 |
Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
tacrolimus (anhydrous) | down-regulates
chemical inhibition
|
PPP3CC |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127245 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15276472 |
Calcineurin catalytic activity is inhibited by the immunosuppressive drugs cyclosporine and fk506 through complexes with immunophilin proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CC | up-regulates
relocalization, dephosphorylation
|
NFATC2 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-233441 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18676376 |
Calcineurin dephosphorylates members of the nuclear factor of activated T cells (NFAT)2 transcription factor family, allowing NFAT to translocate to the nucleus where it cooperates with other transcription factors to induce transcription of target genes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
cyclosporin A | down-regulates
chemical inhibition
|
PPP3CC |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127231 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15276472 |
Calcineurin catalytic activity is inhibited by the immunosuppressive drugs cyclosporine and fk506 through complexes with immunophilin proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPP3CC
- 
- 