Summary

Name CYP2R1
Full Name Vitamin D 25-hydroxylase
Synonyms Cytochrome P450 2R1 |
Primary ID Q6VVX0
Links - -
Type protein
Relations 2
Pathways Vitamin-D Metabolism
Function A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070).

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Relations

Regulator Mechanism target score ℹ
+ CYP2R1down-regulates quantity img/direct_inhibition.png chemical modification vitamin D 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
Pathways:Vitamin-D Metabolism
+ CYP2R1up-regulates quantity img/direct-activation.png chemical modification calcidiol 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
Pathways:Vitamin-D Metabolism