+ |
ROCK1 | down-regulates
phosphorylation
|
MPRIP |
0.296 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-157593 |
|
|
Homo sapiens |
|
pmid |
sentence |
17761936 |
Enhanced rho kinase activity induces endothelial barrier dysfunction by a contractile mechanism via inactivation of myosin phosphatase (mp).. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPM1B | down-regulates activity
dephosphorylation
|
MPRIP |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277019 |
|
|
Homo sapiens |
|
pmid |
sentence |
25751141 |
Ppm1b prevents Rip3 auto-activation in resting cells.|Together, these data demonstrate that Ppm1b dephosphorylates Rip3 and thus negatively regulates TNF induced necroptosis in L929 cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RIPK1 | up-regulates activity
phosphorylation
|
MPRIP |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279755 |
|
|
Homo sapiens |
|
pmid |
sentence |
24653026 |
Under such conditions, RIP1 phosphorylates and activates RIP3, which in turn phosphorylates its downstream substrate MLKL, leading to plasma membrane rupture and necrosis( xref ). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |