Summary

Name IL34
Full Name Interleukin-34
Synonyms IL-34 | C16orf77
Primary ID Q6ZMJ4
Links - -
Type protein
Relations 2
Pathways iCAF signaling in PDAC, Monocyte: Macrophage differentiation
Function Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

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Relations

Regulator Mechanism target score ℹ
+ IL34up-regulates activity img/direct-activation.png binding CSF1R 0.909
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle