+ |
SRCAP | up-regulates quantity by expression
transcriptional regulation
|
KLK3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255220 |
|
|
Homo sapiens |
PrEC Cell |
pmid |
sentence |
20432434 |
ShRNA mediated knockdown of SRCAP resulted in decreased H2A.Z binding at the enhancer region of the PSA promoter and decreased expression of PSA in prostate cancer cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SRCAP | up-regulates activity
binding
|
AR |
0.42 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255221 |
|
|
Homo sapiens |
|
pmid |
sentence |
20432434 |
The SNF2-related CBP activator protein (SRCAP) serves as a coactivator for several nuclear receptors including the androgen receptor (AR). SRCAP is an ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes. In this report, we demonstrate that SRCAP is expressed in the epithelium of normal prostate and in prostate carcinoma cells, and is associated with AR in the nucleus |
|
Publications: |
1 |
Organism: |
Homo Sapiens |