Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273881 |
Tyr327 |
KKPLDGEyFTLQIRG |
Homo sapiens |
|
pmid |
sentence |
32561851 |
Here, we describe a function for NEK10 in the regulation of p53 transcriptional activity through tyrosine phosphorylation. NEK10 loss increases cellular proliferation by modulating the p53-dependent transcriptional output. NEK10 directly phosphorylates p53 on Y327, revealing NEK10's unexpected substrate specificity. A p53 mutant at this site (Y327F) acts as a hypomorph, causing an attenuated p53-mediated transcriptional response. |
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