Relation Results

Summary

Name ZNF365
Full Name Protein ZNF365
Synonyms DISC1-binding zinc-finger protein, Protein su48 | DBZ, KIAA0844
Primary ID Q70YC5
Links - -
Type protein
Relations 2
Function Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in ...
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Type: Score: Layout: SPV 
0.2930.2TP53ZNF365PARP1

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Relations
Regulator
Mechanism
target
score ℹ
+ TP53up-regulates quantity by expression img/direct-activation.png transcriptional regulation ZNF365 0.293
Identifier Residue Sequence Organism Cell Line
SIGNOR-272476 Homo sapiens
pmid sentence
Here, analysis of p53-regulated genes activated in the setting of telomere dysfunction identified Zfp365 (ZNF365 in humans) as a direct p53 target that promotes genome stability| Our study identified ZNF365 as a necessary target whose activation by p53 in the presence of critically short telomeres contributes to genomic stability. We provide evidence that loss of ZNF365 leads to increased expression of CFS and dysfunctional telomeres, aberrant sister telomere recombination, and increased aneuploidy
Publications: 1 Organism: Homo Sapiens
+ ZNF365up-regulates activity img/direct-activation.png binding PARP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272477 Homo sapiens
pmid sentence
We identified ZNF365 as a necessary component of the HR repair pathway. ZNF365 interacts with PARP1 and tethers MRE11 to the nucleolytic resection sites for replication fork recovery
Publications: 1 Organism: Homo Sapiens
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