| + |
ATAT1 | up-regulates quantity by stabilization 
acetylation
|
TUBA1A |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272251 |
Lys40 |
DGQMPSDkTIGGGDD |
in vitro |
|
| pmid |
sentence |
| 29703898 |
Alpha-Tubulin acetyltransferase (alphaTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes, and protozoa, and its activity plays a conserved role in several microtubule-based processes.|The tubulin subunits of microtubules are acetylated, and lysine-40 (K40) of the alpha-tubulin subunit has been identified as an important conserved site of microtubule acetylation (6–8). This modification is considered a hallmark of stable, long-lived microtubules |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
TUBA1A | up-regulates 
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269725 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDNF | down-regulates quantity by repression 
transcriptional regulation
|
TUBA1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252174 |
|
|
Rattus norvegicus |
Neural Stem Cell |
| pmid |
sentence |
| 15212950 |
We characterize the network of 43 genes induced by GDNF overproduction of neuronal progenitor cells (ST14A), which mainly regulate migration and differentiation of neuronal progenitor cells. GDNF down-regulates doublecortin, Paf-ah1b (Lis1), dynamin, and a-tubulin, which are involved in neocortical lamination and cytoskeletal reorganization. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Elongator complex | up-regulates activity
acetylation
|
TUBA1A |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269717 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
Elongator Subunits Interact with the Microtubules and Are Required for Proper Acetylation of α-Tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMA1 | up-regulates
binding
|
TUBA1A |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116640 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11956313 |
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXJ1 | up-regulates quantity by expression
transcriptional regulation
|
TUBA1A |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266938 |
|
|
Homo sapiens |
Basal Cell |
| pmid |
sentence |
| 23822649 |
FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sperm associated antigen 6 (SPAG6); tektin 1 (TEKT1), TEKT2 and tubulin, alpha 1a (TUBA1A; Figure 3C and Additional file 2: Table S1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTL | down-regulates 
tyrosination
|
TUBA1A |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176912 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22020298 |
Tubulin tyrosine ligase (ttl) adds a c-terminal tyr to __tubulin as part of a tyrosination/detyrosination cycle present in most eukaryotic cells. / ttl inhibits spontaneous tubulin polymerization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
vincaleukoblastine sulfate | down-regulates activity
chemical inhibition
|
TUBA1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15579115 |
Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TUBA1A
- 
- 