Relation Results

Summary

Name TUBA1A
Full Name Tubulin alpha-1A chain
Synonyms Alpha-tubulin 3, Tubulin B-alpha-1, Tubulin alpha-3 chain | TUBA3
Primary ID Q71U36
Links - -
Type protein
Relations 8
Inhibitors vincaleukoblastine sulfate
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeab ...
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Type: Score: Layout: SPV 
0.2710.70.4180.3010.5210.20.80.336ATAT1TUBA1ANeuron_migrationNUMA1FOXJ1TTLGDNFvincaleukoblastine sulfateElongator complex

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ATAT1up-regulates quantity by stabilization img/direct-activation.png acetylation TUBA1A 0.271
Identifier Residue Sequence Organism Cell Line
SIGNOR-272251 Lys40 DGQMPSDkTIGGGDD in vitro
pmid sentence
Alpha-Tubulin acetyltransferase (alphaTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes, and protozoa, and its activity plays a conserved role in several microtubule-based processes.|The tubulin subunits of microtubules are acetylated, and lysine-40 (K40) of the alpha-tubulin subunit has been identified as an important conserved site of microtubule acetylation (6–8). This modification is considered a hallmark of stable, long-lived microtubules
Publications: 1 Organism: In Vitro
+ TUBA1Aup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269725 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ NUMA1up-regulates img/direct-activation.png binding TUBA1A 0.418
Identifier Residue Sequence Organism Cell Line
SIGNOR-116640 Homo sapiens
pmid sentence
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.
Publications: 1 Organism: Homo Sapiens
+ FOXJ1up-regulates quantity by expression img/direct-activation.png transcriptional regulation TUBA1A 0.301
Identifier Residue Sequence Organism Cell Line
SIGNOR-266938 Homo sapiens Basal Cell
pmid sentence
FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sperm associated antigen 6 (SPAG6); tektin 1 (TEKT1), TEKT2 and tubulin, alpha 1a (TUBA1A; Figure 3C and Additional file 2: Table S1).
Publications: 1 Organism: Homo Sapiens
+ TTLdown-regulates img/direct_inhibition.png tyrosination TUBA1A 0.521
Identifier Residue Sequence Organism Cell Line
SIGNOR-176912 Homo sapiens
pmid sentence
Tubulin tyrosine ligase (ttl) adds a c-terminal tyr to __tubulin as part of a tyrosination/detyrosination cycle present in most eukaryotic cells. / ttl inhibits spontaneous tubulin polymerization
Publications: 1 Organism: Homo Sapiens
+ GDNFdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TUBA1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252174 Rattus norvegicus Neural Stem Cell
pmid sentence
We characterize the network of 43 genes induced by GDNF overproduction of neuronal progenitor cells (ST14A), which mainly regulate migration and differentiation of neuronal progenitor cells. GDNF down-regulates doublecortin, Paf-ah1b (Lis1), dynamin, and a-tubulin, which are involved in neocortical lamination and cytoskeletal reorganization.
Publications: 1 Organism: Rattus Norvegicus
+ vincaleukoblastine sulfatedown-regulates activity img/direct_inhibition.png chemical inhibition TUBA1A 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259255 Homo sapiens
pmid sentence
Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs.
Publications: 1 Organism: Homo Sapiens
+ Elongator complexup-regulates activity img/direct-activation.png acetylation TUBA1A 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-269717 Homo sapiens HEK-293 Cell
pmid sentence
Elongator Subunits Interact with the Microtubules and Are Required for Proper Acetylation of α-Tubulin.
Publications: 1 Organism: Homo Sapiens
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